From: Antifilarial activity of diterpenoids from Taxodium distichum
Antifilarial agent | Dose mg/kg s.c. × 5 days (n) | Worms recovered | Sterilised female worm count (%) | ||
---|---|---|---|---|---|
Male | Female | Total (% reduction over untreated) | Â | ||
A001 (Crude extract) | 500 p.o. (6) | 0 | 0 | 0*** (5) | –2 (28.57) |
11.00 (1)b | |||||
K003 | 100 (5) | 0.40 ± 0.89 | 8.00 ± 0.71 | 8.40 ± 1.14 | 8.00 ± 0.71 |
(27.12) | (>Â 95)*** | ||||
K004 | 100 (5) | 0 | 8.00 ± 0.82 | 8.00 ± 0.82 | 1.50 ± 0.58 |
(32.20) | (18.85 ± 7.22) | ||||
Ivermectina | 1 (4) | 2.75 ± 0.96 | 6.25 ± 1.50 | 9.67 ± 2.52 | 2.75 ± 0.96 |
(22.43) | (44.29 ± 5.15)** | ||||
DEC-Ca | 25 (6) | 2.60 ± 0.55 | 6.60 ± 1.14 | 9.20 ± 1.48 | 0.60 ± 0.89 |
(22.03) | (7.86 ± 11.41) | ||||
Control (Vehicle treated) | – (5) | 3.40 ± 1.97 | 8.40 ± 2.07 | 11.80 ± 0.45 | 0.40 ± 0.55 |
(5.71 ± 7.82) |