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Table 2 Antifilarial activity of crude extract of aerial parts of Taxodium distichum, its molecules, and the reference drugs ivermectin and DEC against Brugia malayi in jirds, Meriones unguiculatus (mean ± standard deviation)

From: Antifilarial activity of diterpenoids from Taxodium distichum

Antifilarial agent Dose mg/kg s.c. × 5 days (n) Worms recovered Sterilised female worm count (%)
Male Female Total (% reduction over untreated)  
A001 (Crude extract) 500 p.o. (6) 0 0 0*** (5) –2 (28.57)
11.00 (1)b
K003 100 (5) 0.40 ± 0.89 8.00 ± 0.71 8.40 ± 1.14 8.00 ± 0.71
(27.12) (> 95)***
K004 100 (5) 0 8.00 ± 0.82 8.00 ± 0.82 1.50 ± 0.58
(32.20) (18.85 ± 7.22)
Ivermectina 1 (4) 2.75 ± 0.96 6.25 ± 1.50 9.67 ± 2.52 2.75 ± 0.96
(22.43) (44.29 ± 5.15)**
DEC-Ca 25 (6) 2.60 ± 0.55 6.60 ± 1.14 9.20 ± 1.48 0.60 ± 0.89
(22.03) (7.86 ± 11.41)
Control (Vehicle treated) – (5) 3.40 ± 1.97 8.40 ± 2.07 11.80 ± 0.45 0.40 ± 0.55
(5.71 ± 7.82)
  1. aReference drugs; DEC-C: Diethylcarbamazine-Citrate
  2. bOne animal showed presence of live adult worms but not dead/calcified worms
  3. **P < 0.01 (ivermectin vs Control/DEC/K004); ***P < 0.001 (K003 vs control/K004/ivermectin/DEC; A001 vs control/K003/K004/ivermectin/DEC)