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Table 2 Antifilarial activity of crude extract of aerial parts of Taxodium distichum, its molecules, and the reference drugs ivermectin and DEC against Brugia malayi in jirds, Meriones unguiculatus (mean ± standard deviation)

From: Antifilarial activity of diterpenoids from Taxodium distichum

Antifilarial agent

Dose mg/kg s.c. × 5 days (n)

Worms recovered

Sterilised female worm count (%)

Male

Female

Total (% reduction over untreated)

 

A001 (Crude extract)

500 p.o. (6)

0

0

0*** (5)

–2 (28.57)

11.00 (1)b

K003

100 (5)

0.40 ± 0.89

8.00 ± 0.71

8.40 ± 1.14

8.00 ± 0.71

(27.12)

(> 95)***

K004

100 (5)

0

8.00 ± 0.82

8.00 ± 0.82

1.50 ± 0.58

(32.20)

(18.85 ± 7.22)

Ivermectina

1 (4)

2.75 ± 0.96

6.25 ± 1.50

9.67 ± 2.52

2.75 ± 0.96

(22.43)

(44.29 ± 5.15)**

DEC-Ca

25 (6)

2.60 ± 0.55

6.60 ± 1.14

9.20 ± 1.48

0.60 ± 0.89

(22.03)

(7.86 ± 11.41)

Control (Vehicle treated)

– (5)

3.40 ± 1.97

8.40 ± 2.07

11.80 ± 0.45

0.40 ± 0.55

(5.71 ± 7.82)

  1. aReference drugs; DEC-C: Diethylcarbamazine-Citrate
  2. bOne animal showed presence of live adult worms but not dead/calcified worms
  3. **P < 0.01 (ivermectin vs Control/DEC/K004); ***P < 0.001 (K003 vs control/K004/ivermectin/DEC; A001 vs control/K003/K004/ivermectin/DEC)