Clinical staging | Gender/median [range] of age in months | Serology | Clinical signs (number of dogs/total number of dogs, %) | Laboratory findings (number of dogs/total number of dogs, %) |
---|---|---|---|---|
I-mild disease (n = 10) | 5 females and 4 males/15.2 [5–40] | Negative to low positive antibody levels | Papular dermatitis (10/10, 100 %) | No abnormalities observed |
IIa-moderate disease (n = 27) | 11 females and 16 males/51 [5–153] | Low to high positive antibody levels | Cutaneous lesions (20/27, 74 %): • Exfoliative dermatitis (9/27, 33 %) • Ulcerative dermatitis (9/27, 33 %) • Alopecia (7/27, 26 %) • Nodular dermatitis (3/27, 11 %) • Papular dermatitis (2/27, 7 %) • Ischemic dermatopathy (1/27, 4 %) Lymphadenomegaly (19/27, 70 %) Weight loss (8/27, 30 %) Fever (5/27, 19 %) Ocular lesions (4/27, 15 %): • Conjunctivitis (3/27, 11 %) • Blepharitis (1/27, 4 %) Lameness (4/27, 15 %) Vomiting and/or diarrhea (2/27, 7 %) Inspiratory dyspnea (1/27, 4 %) Masseter myositis (1/27, 4 %) Muscle atrophy (1/27, 4 %) Epistaxis (1/27, 4 %) | Mild to moderate normocytic normochromic non-regenerative anemia (8/26, 31 %; 3/26, 12 %, respectively) Mild leukocytosis with mature neutrophilia (2/26, 8 %) Mild to moderate thrombocytopenia (2/26, 8 %) Mild leucopenia with lymphopenia and neutropenia (2/26, 8 %) Hyperproteinemia (13/27, 48 %) Hypergammaglobulinemia (14/27, 52 %) Hyperbetaglobulinemia (15/27, 55 %) Hypoalbuminemia (6/26, 23 %) |
IIb-moderate disease (n = 9) | 2 females and 9 males/43 [9–147] | Medium to high positive antibody levels | Cutaneous lesions (7/9, 77 %): • Exfoliative dermatitis (3/9, 33 %) • Ulcerative dermatitis (3/9, 33 %) • Alopecia (2/9, 22 %) Lymphadenomegaly (6/9, 67 %) Weight loss (5/9, 56 %) Ocular lesions (4/9, 44 %): • Conjunctivitis (2/9, 22 %) • Bilateral blepharitis (2/9, 22 %) Vomiting and/or diarrhea (3/9, 33 %) Lethargy (2/9, 22 %) Lameness and articular pain (1/9, 33 %) Polyuria and polydipsia (1/9, 11 %) | Mild to moderate normocytic normochromic non-regenerative anemia (6/9, 67 %; 2/9, 22 %, respectively) Mild leukocytosis with mild mature neutrophilia (2/9, 22 %) Lymphopenia (3/9, 33 %) Hyperproteinemia (7/9, 77 %) Hypergammaglobulinemia (9/9, 100 %) Hyperbetaglobulinemia (6/9, 66 %) Hypoalbuminemia (6/9, 66 %) |
III-severe disease (n = 10) | 5 females and 4 males/85 [37–132] | Medium to high positive antibody levels | Lymphadenomegaly (7/10, 70 %) Cutaneous lesions (6/10, 60 %): • Exfoliative dermatitis (4/10, 40 %) • Alopecia (1/10, 10 %) • Ulcerative dermatitis (2/10, 20 %) Weight loss (5/10, 50 %) Ocular lesions (3/10, 30 %): • Bilateral blepharitis (1/10, 10 %) • Conjunctivitis (1/10, 10 %) • Superficial keratitis (1/10, 10 %) Lethargy and anorexia (2/10, 20 %) Vomiting and/or diarrhea (2/10, 20 %) Splenomegaly (2/10, 20 %) Lameness and articular pain (1/10, 10 %) Muscle atrophy (1/10, 10 %) Epistaxis (1/10, 11 %) Polyuria and polydipsia (1/10, 10 %) Fever (1/10, 10 %) Chronic weakness (1/10, 10 %) | Mild normocytic normochromic non-regenerative anemia (6/9, 67 %) Moderate regenerative anemia (2/9, 22 %) Thrombocytosis (1/9, 11 %) Mild thrombocytopenia (1/9, 11 %) Mild leukocytosis with mature neutrophilia (2/9, 22 %) Mild leukopenia with lymphopenia and neutropenia (1/9, 11 %) Lymphopenia (1/9, 11 %) Mild lymphocytosis (1/9, 11 %) Hyperproteinemia (8/10, 80 %) Hypergammaglobulinemia (9/10, 90 %) Hyperbetaglobulinemia (9/10, 90 %) Hypoalbuminemia (9/10, 90 %) Proteinuria (UPC) (10/10, 100 %) |
IV-very severe disease (n = 4) | 2 females and 2 males/7.5 [23–120] | Medium to high positive antibody levels | Weight loss (3/4, 75 %) Cutaneous lesions (3/4, 75 %): • Exfoliative dermatitis (2/4, 50 %) • Ulcerative dermatitis (1/4, 25 %) • Onicogriphosis (1/4, 25 %) • Ulcerative and nodular blepharitis (1/4, 25 %) Vomiting and/or diarrhea (2/4, 50 %) Lymphadenomegaly (1/4, 25 %) Cachexy (1/4, 25 %) Hypertension (1/4, 25 %) Cardiac insufficiency (1/4, 25 %) Keratoconjunctivitis (1/4, 25 %) Chronic weakness (1/4, 25 %) Paraparesis (1/4, 25 %) | Mild normocytic normochromic non regenerative anemia (1/4, 25 %; 3/4, 75 %, respectively) Thrombocytosis (2/4, 50 %) Lymphopenia (1/4, 25 %) Mild leukocytosis with mature neutrophilia (1/4, 25 %) Total protein (4/4, 100 %) Hypoalbuminemia ((4/4, 100 %) Hypergammaglobulinemia (3/3, 100 %) Hyperbetaglobulinemia (3/3, 100 %) Proteinuria (UPC) (4/4, 100 %) Renal azotemia (3/3, 100 %) |