Fig. 1

a Inhibitory properties of the 74 compounds at 20 μM on exsheathed third-stage larvae (xL3s) are displayed as the percent of motility compared with the positive (+) and negative (−) controls. Negative controls were xL3 treated with Luria Bertani (LB) medium supplemented with 100 IU/ml of penicillin, 100 μg/ml of streptomycin and 2.5 μg/ml of amphotericin (LB*) containing 0.5 % dimethyl sulfoxide (DMSO) or methanol (MeOH); LB* + 0.5 % DMSO/MeOH. b The structures and motility indices of compounds that have a similar structure to the active compounds, MJ-17, MJ-22 and WZY-2 (bold), are also shown for comparative purposes. The motility indices for individual compounds were calculated from the mean of triplicate motility indices, with the variance represented by the standard error of the mean (± SEM)