Table 1 Testing of selenophene and thiophene-core ligands (WZY-2 and MJ-22, MJ-17) on Haemonchus contortus in the biological assay. A comparison of the ‘half of the maximum inhibitory concentration’ (IC₅₀) values of individual ligands with those of the two reference anthelmintics (monepantel and moxidectin)

24 h

10.0^a

6.6^b

25.7^a,b

~52.1

2.5

48 h

13.0^c

7.2^d

25.6^c,d,g

6.0

2.5

72 h

12.1^e

9.6^f

23.8^e,f,h

0.4

2.3

24 h

9.3

6.4

13.9

4.3

2.2

48 h

6.1

3.2

6.2^g

2.2

0.60

72 h

6.2

6.2

6.1^h

3.0

0.0045

7 days

12.2

10.5

13.7

0.4

12.3