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Table 1 In vitro activity profile of 56 FDA compounds (including 2 reference compounds) against A. ceylanicum and T. muris adult and larval stages

From: Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections

Compound Drug effect (%)
A. ceylanicum L3 200 μM (72 h) H. polygyrus L3 200 μM (72 h) T. muris L1 100 μM (24 h) A. ceylanicum adult 50 μM (72 h) H. polyygrus adult 50 μM (72 h) T. muris adult 50 μM (72 h)
Levamisole 100 100 100 0 56 100
Ivermectin 100 93 0 100 41 0
Abamectin 100 ND, anthelmintic
Amitriptyline HCl 91 ND, toxic
Apomorphine HCl 72 ND, toxic
Bifonazole 67 ND, topical application
Bitoscanate 100 20 100 28 34 100
Carbachol 89 ND, topical application
Chlorambucil 95 ND, toxic
Chlorcyclizine HCl 78 77 78 23 30 31
Chlorhexidine dihydrochloride 61 ND, topical application
Chloroxylenol 100 ND, topical application
Chlorpromazine 100 ND, toxic
Chlorprothixene HCl 100 ND, toxic
Chlorpyrifos 97 ND, toxic
Cisplatin 87 ND, toxic
Clemastine fumarate 76 91 2 47 30 100
Clomiphene citrate 80 ND, toxic
Coumophos 100 ND, toxic
Cyproheptadine HCl 88 ND, toxic
Dexlansoprazole 88 35 1 47 17 55
Diatrizoic acid 81 ND, toxic
Dibenzothiophene 100 ND, topical application
Dicyclomine HCl 71 88 7 42 100 93
Dimpylate 100 ND, toxic
Doramectin 100 ND, anthelmintic
Doxepin HCl 64 ND, toxic
Drofenine HCl 62 87 100 44 20 100
Dyclonine HCl 100 ND, topical
Eprinomectin 100 ND, anthelmintic
Ethopropazine HCl 100 89 100 33 100 100
Fenbendazole 66 ND, anthelmintic
Fenthion 97 ND, toxic
Ftaxilide 73 ND, commercially not available
Hexachlorophene 100 ND, topical
Histamine dihydrochloride 62 ND, topical
Mebendazole 78 ND, anthelmintic
Metformin HCl 100 11 100 50 27 75
Metitepine mesylate 70 ND, toxic
Morantel citrate 60 100 100 47 80 94
Moxidectin 100 ND, anthelmintic
Natamycin 95 14 100 53 10 61
Phenothiazine 98 ND, toxic
Phenylmercuric acetate 100 ND, topical
Pramoxine HCl 100 ND, topical
Pyrantel pamoate 91 ND, anthelmintic
Selamectin 79 ND, anthelmintic, topical
Tetramizole HCl 100 ND, anthelmintic
Thiabendazole 93 ND, anthelmintic
Thonzonium bromide 98 ND, topical
Trichlorfon 100 89 100 100 79 100
Triclosan 98 ND, topical
Triflupromazine HCl 83 ND, toxic
Trimeprazine tartrate 64 ND, toxic
Trimipramine maleate 62 79 99 7 23 75
Zoxazolamine 98 ND, toxic
  1. AbbreviationND Not done