Skip to main content

Table 1 In vitro activity profile of 56 FDA compounds (including 2 reference compounds) against A. ceylanicum and T. muris adult and larval stages

From: Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections

Compound

Drug effect (%)

A. ceylanicum L3 200 μM (72 h)

H. polygyrus L3 200 μM (72 h)

T. muris L1 100 μM (24 h)

A. ceylanicum adult 50 μM (72 h)

H. polyygrus adult 50 μM (72 h)

T. muris adult 50 μM (72 h)

Levamisole

100

100

100

0

56

100

Ivermectin

100

93

0

100

41

0

Abamectin

100

ND, anthelmintic

Amitriptyline HCl

91

ND, toxic

Apomorphine HCl

72

ND, toxic

Bifonazole

67

ND, topical application

Bitoscanate

100

20

100

28

34

100

Carbachol

89

ND, topical application

Chlorambucil

95

ND, toxic

Chlorcyclizine HCl

78

77

78

23

30

31

Chlorhexidine dihydrochloride

61

ND, topical application

Chloroxylenol

100

ND, topical application

Chlorpromazine

100

ND, toxic

Chlorprothixene HCl

100

ND, toxic

Chlorpyrifos

97

ND, toxic

Cisplatin

87

ND, toxic

Clemastine fumarate

76

91

2

47

30

100

Clomiphene citrate

80

ND, toxic

Coumophos

100

ND, toxic

Cyproheptadine HCl

88

ND, toxic

Dexlansoprazole

88

35

1

47

17

55

Diatrizoic acid

81

ND, toxic

Dibenzothiophene

100

ND, topical application

Dicyclomine HCl

71

88

7

42

100

93

Dimpylate

100

ND, toxic

Doramectin

100

ND, anthelmintic

Doxepin HCl

64

ND, toxic

Drofenine HCl

62

87

100

44

20

100

Dyclonine HCl

100

ND, topical

Eprinomectin

100

ND, anthelmintic

Ethopropazine HCl

100

89

100

33

100

100

Fenbendazole

66

ND, anthelmintic

Fenthion

97

ND, toxic

Ftaxilide

73

ND, commercially not available

Hexachlorophene

100

ND, topical

Histamine dihydrochloride

62

ND, topical

Mebendazole

78

ND, anthelmintic

Metformin HCl

100

11

100

50

27

75

Metitepine mesylate

70

ND, toxic

Morantel citrate

60

100

100

47

80

94

Moxidectin

100

ND, anthelmintic

Natamycin

95

14

100

53

10

61

Phenothiazine

98

ND, toxic

Phenylmercuric acetate

100

ND, topical

Pramoxine HCl

100

ND, topical

Pyrantel pamoate

91

ND, anthelmintic

Selamectin

79

ND, anthelmintic, topical

Tetramizole HCl

100

ND, anthelmintic

Thiabendazole

93

ND, anthelmintic

Thonzonium bromide

98

ND, topical

Trichlorfon

100

89

100

100

79

100

Triclosan

98

ND, topical

Triflupromazine HCl

83

ND, toxic

Trimeprazine tartrate

64

ND, toxic

Trimipramine maleate

62

79

99

7

23

75

Zoxazolamine

98

ND, toxic

  1. Abbreviation: ND Not done