|
Treatment
|
Dose (mg/kg)
|
T. muris
|
H. polygyrus
|
|---|
|
No. of mice cured/investigated
|
Average worm number
|
Worm burden reduction (%)
|
Worm expulsion rate (%)
|
No. of mice cured/investigated
|
Average worm number
|
Worm burden reduction (%)
|
|---|
|
Control a
|
–
|
0/6
|
170.95
|
–
|
–
|
–
|
---
|
---
|
|
Control b
|
–
|
0/4
|
163.5
|
–
|
–
|
–
|
---
|
---
|
|
Control c
|
–
|
0/4
|
197.3
|
–
|
–
|
–
|
---
|
---
|
|
Control 1
| | | | | |
0/8
|
61.3
|
---
|
|
Control 2
| | | | | |
0/8
|
21.1
| |
|
Control 3
| | | | | |
0/12
|
47.0
| |
|
Bitoscanatea,3
|
100
|
0/3*
|
70.5
|
58.8
|
0.3
|
4/4
|
0
|
100
|
|
Bitoscanate2
|
50
|
ND
|
–
|
–
|
–
|
3/4
|
0.25
|
98.8¶
|
|
Chlorcyclizine HClc,1
|
100
|
0/3
|
115.0
|
41.7
| |
0/4
|
39.5
|
35.6
|
|
Clemastineb,1
|
100
|
0/3
|
130.7
|
20.1
|
2.5
|
0/4
|
84.8
|
0
|
|
Dicyclomine HClb,1
|
400
|
0/3
|
245.5
|
0
|
39.1
|
0/4
|
36.8
|
40.1
|
|
Drofenine HCla,1
|
400
|
0/3
|
267.6
|
0
|
3.1
|
0/4
|
54.0
|
12.0
|
|
Ethoproprazine HClb,1
|
200
|
0/3
|
368.0
|
0
|
6.7
|
0/4
|
45.5
|
25.8
|
|
Lansoprazole1
|
400
|
ND
|
–
|
–
|
–
|
0/4
|
43.0
|
29.9
|
|
Metformin HCla,1
|
400
|
0/3
|
140.6
|
17.7
|
0.6
|
0/4
|
80.0
|
0
|
|
Morantelc,1
|
400
|
0/3**
|
367.0
|
0
|
0
|
0/2**
| | |
|
Natamycina,1
|
400
|
0/3***
|
–
|
–
|
–
|
2/4
|
24.8
|
59.7
|
|
Trichlorfonc,1
|
200
|
1/3
|
34.0
|
80.1¶
|
67.6
|
3/4
|
0.5
|
98.9¶
|
|
Trichlorfona
|
100
|
0/3
|
121.0
|
28.8
|
3.3
|
2/4
|
8.5
|
81.9¶
|
|
Trimipramine maleatec,1
|
10
|
0/3
|
113.3
|
42.6
|
0.1
|
0/4
|
71.5
|
0
|
- Each * indicates a mouse that died. Superscripts 1–3 and a-c refer to the respective control groups ¶
P < 0.05
