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Table 2 In vivo studies against H. polygyrus and T. muris

From: Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections

Treatment Dose (mg/kg) T. muris H. polygyrus
No. of mice cured/investigated Average worm number Worm burden reduction (%) Worm expulsion rate (%) No. of mice cured/investigated Average worm number Worm burden reduction (%)
Control a 0/6 170.95 --- ---
Control b 0/4 163.5 --- ---
Control c 0/4 197.3 --- ---
Control 1       0/8 61.3 ---
Control 2       0/8 21.1  
Control 3       0/12 47.0  
Bitoscanatea,3 100 0/3* 70.5 58.8 0.3 4/4 0 100
Bitoscanate2 50 ND 3/4 0.25 98.8
Chlorcyclizine HClc,1 100 0/3 115.0 41.7   0/4 39.5 35.6
Clemastineb,1 100 0/3 130.7 20.1 2.5 0/4 84.8 0
Dicyclomine HClb,1 400 0/3 245.5 0 39.1 0/4 36.8 40.1
Drofenine HCla,1 400 0/3 267.6 0 3.1 0/4 54.0 12.0
Ethoproprazine HClb,1 200 0/3 368.0 0 6.7 0/4 45.5 25.8
Lansoprazole1 400 ND 0/4 43.0 29.9
Metformin HCla,1 400 0/3 140.6 17.7 0.6 0/4 80.0 0
Morantelc,1 400 0/3** 367.0 0 0 0/2**   
Natamycina,1 400 0/3*** 2/4 24.8 59.7
Trichlorfonc,1 200 1/3 34.0 80.1 67.6 3/4 0.5 98.9
Trichlorfona 100 0/3 121.0 28.8 3.3 2/4 8.5 81.9
Trimipramine maleatec,1 10 0/3 113.3 42.6 0.1 0/4 71.5 0
  1. Each * indicates a mouse that died. Superscripts 1–3 and a-c refer to the respective control groups P < 0.05