Table 2 In vivo studies against H. polygyrus and T. muris
Treatment | Dose (mg/kg) | T. muris | H. polygyrus | |||||
|---|---|---|---|---|---|---|---|---|
No. of mice cured/investigated | Average worm number | Worm burden reduction (%) | Worm expulsion rate (%) | No. of mice cured/investigated | Average worm number | Worm burden reduction (%) | ||
Control a | – | 0/6 | 170.95 | – | – | – | --- | --- |
Control b | – | 0/4 | 163.5 | – | – | – | --- | --- |
Control c | – | 0/4 | 197.3 | – | – | – | --- | --- |
Control 1 | 0/8 | 61.3 | --- | |||||
Control 2 | 0/8 | 21.1 | ||||||
Control 3 | 0/12 | 47.0 | ||||||
Bitoscanatea,3 | 100 | 0/3* | 70.5 | 58.8 | 0.3 | 4/4 | 0 | 100 |
Bitoscanate2 | 50 | ND | – | – | – | 3/4 | 0.25 | 98.8¶ |
Chlorcyclizine HClc,1 | 100 | 0/3 | 115.0 | 41.7 | 0/4 | 39.5 | 35.6 | |
Clemastineb,1 | 100 | 0/3 | 130.7 | 20.1 | 2.5 | 0/4 | 84.8 | 0 |
Dicyclomine HClb,1 | 400 | 0/3 | 245.5 | 0 | 39.1 | 0/4 | 36.8 | 40.1 |
Drofenine HCla,1 | 400 | 0/3 | 267.6 | 0 | 3.1 | 0/4 | 54.0 | 12.0 |
Ethoproprazine HClb,1 | 200 | 0/3 | 368.0 | 0 | 6.7 | 0/4 | 45.5 | 25.8 |
Lansoprazole1 | 400 | ND | – | – | – | 0/4 | 43.0 | 29.9 |
Metformin HCla,1 | 400 | 0/3 | 140.6 | 17.7 | 0.6 | 0/4 | 80.0 | 0 |
Morantelc,1 | 400 | 0/3** | 367.0 | 0 | 0 | 0/2** | ||
Natamycina,1 | 400 | 0/3*** | – | – | – | 2/4 | 24.8 | 59.7 |
Trichlorfonc,1 | 200 | 1/3 | 34.0 | 80.1¶ | 67.6 | 3/4 | 0.5 | 98.9¶ |
Trichlorfona | 100 | 0/3 | 121.0 | 28.8 | 3.3 | 2/4 | 8.5 | 81.9¶ |
Trimipramine maleatec,1 | 10 | 0/3 | 113.3 | 42.6 | 0.1 | 0/4 | 71.5 | 0 |