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Table 1 Effect of IGF-I on parasitism in THP-1 with isolates of Leishmania

From: Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis

Leishmania from CL ML DL
IGF-I (50 ng/ml) + + +
Parasite isolates 124 107 139 199 255 180
78 87 146 148 110 133
449 455 73 73 33 33
140 145 177 182 36 28
135 161 108 126 122 125
412 365 38 45 33 34
85 106 106 136 38 30
153 133     
  1. THP-1 cells were infected with the isolates of L. (V.) braziliensis from patients with cutaneous (CL, n = 8), mucosal (ML, n = 7) or disseminated (DL, n = 7) forms of the disease and stimulated or not with IGF-I (50 ng/ml) throughout the culture period of 48 h. Parasitism was evaluated by optical microscopy and the result is represented as the number of parasites per 100 cells. Results representative of two experiments with each isolate tested in triplicate