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Table 1 Effect of IGF-I on parasitism in THP-1 with isolates of Leishmania

From: Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis

Leishmania from

CL

ML

DL

IGF-I (50 ng/ml)

+

+

+

Parasite isolates

124

107

139

199

255

180

78

87

146

148

110

133

449

455

73

73

33

33

140

145

177

182

36

28

135

161

108

126

122

125

412

365

38

45

33

34

85

106

106

136

38

30

153

133

    
  1. THP-1 cells were infected with the isolates of L. (V.) braziliensis from patients with cutaneous (CL, n = 8), mucosal (ML, n = 7) or disseminated (DL, n = 7) forms of the disease and stimulated or not with IGF-I (50 ng/ml) throughout the culture period of 48 h. Parasitism was evaluated by optical microscopy and the result is represented as the number of parasites per 100 cells. Results representative of two experiments with each isolate tested in triplicate