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Table 4 Distribution of Plasmodium falciparum MSP1 and MSP2 allelic families and mean of parasite density among age groups of uncomplicated and severe P. falciparum malaria patients in Gezira State, Sudan (January 2012)

From: Multiplicity of infection and genetic diversity of Plasmodium falciparum isolates from patients with uncomplicated and severe malaria in Gezira State, Sudan

Gene/Allele

Age group (years)

<5

5–19

20–40

>40

Total

n (%)

n (%)

n (%)

n (%)

n (%)

(n = 16)

(n = 53)

(n = 52)

(n = 19)

(n = 140)

MSP1

     

 MAD20

0 (0)

10 (18.9)

6 (11.5)

3 (15.8)

19 (16.7)

 K1

1 (6.3)

4 (7.5)

4 (7.7)

1 (5.3)

10 (8.8)

 RO33

1 (6.3)

4 (7.5)

11 (21.2)

0 (0)

16 (14.0)

 MAD20/K1

3 (18.7)

3 (5.7)

5 (9.6)

3 (15.8)

14 (12.3)

 MAD20/RO33

2 (12.5)

10 (18.9)

6 (11.5)

4 (21.0)

22 (19.3)

 K1/RO33

0 (0)

4 (7.5)

9 (17.3)

4 (21.0)

17 (14.9)

 MAD20/K1/RO33

4 (25.0)

7 (13.2)

3 (5.8)

2 (10.5)

16 (14.0)

 Total

11 (68.8)

42 (79.2)

44 (84.6)

17 (89.4)

114 (100)

MSP2

     

 FC27

2 (12.5)

13 (24.5)

11 (21.2)

5 (26.3)

31 (23.9)

 IC1/3D7

3 (18.8)

10 (18.9)

9 (17.3)

5 (26.3)

27 (20.8)

 FC27/IC1/3D7

8 (50.0)

24 (45.3)

31 (59.6)

9 (47.4)

72 (55.4)

 Total

13 (10.0)

47 (36.2)

51 (39.2)

19 (14.6)

130 (100)

Multiclonal isolates

14 (87.5)

40 (80.0)

41 (78.9)

16 (84.2)

111 (79.3)

Mild malaria n (%)

10 (60.0)

32 (60.0)

35 (67.0)

13 (68.0)

90 (64.3)

Severe malaria n (%)

6 (40.0)

21 (39.0)

17 (32.0)

6 (31.0)

50 (35.7)

Overall MOI

2.6

2.1

2.2

2.4

 

Parasite density (no. of parasites/μl)

5,859.7

14,630.8

13,251.4

24,357.8

 
  1. Abbreviations: n number of individuals, MOI multiplicity of infection