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Table 3 Reduction in egg per gram of faeces (EPGF) in mice infected with 3,000 S. venezuelensis L3 after treatment with aminoalcohol derivatives 4 and 6 and diamine derivatives 17 and 18 for five days at a dose of 20 mg/kg, and ivermectin 0.2 mg/kg

From: In vitro and in vivo evaluation of 2-aminoalkanol and 1,2-alkanediamine derivatives against Strongyloides venezuelensis

Groups

EPGF on day 5

 

EPGF on day 6

 

HDS

EPGF on day 7

 

HDS

 

(Mean ± SEM)

Reduction (%)

(Mean ± SEM)

Reduction (%)

P

(Mean ± SEM)

Reduction (%)

P

Experiment 1

 Infected

2,020 ± 430

24,800 ± 5,210

 

12,5150 ± 9,200

 

 Ivermectin

5,240 ± 580

nr

330 ± 110

99a

<0.001

0 ± 0

100a

< 0.001

 Aminoalcohol 4

3,830 ± 570

nr

20,220 ± 3,080

18

0.274

68,980 ± 12,810

45a

< 0.001

 Aminoalcohol 6

4,720 ± 900

nr

16,160 ± 1970

35a

0.044

61,680 ± 1,917

51a

< 0.001

 ANOVA

F (3, 28) = 3.28; P = 0.051

 

F (3, 28) = 13.42;  P < 0.001

  

F (3, 28) = 45.31; P < 0.001

  

Experiment 2

 Infected

3,190 ± 300

11,060 ± 1,710

 

82,820 ± 5,364

 

 Ivermectin

2,950 ± 300

8

160 ± 90

99a

<0.001

80 ± 50

100a

< 0.001

 Diamine 17

2,715 ± 410

15

10,890 ± 1,200

2

0.912

65,520 ± 7,037

21a

0.025

 Diamine 18

3,410 ± 520

nr

8,110 ± 430

27

0.060

41,450 ± 5,382

50a

< 0.001

ANOVA

F (3, 28) = 0.59; P = 0.625

 

F (3, 28) = 23.03; P < 0.001

  

F (3, 28) = 47.94; P < 0.001

  
  1. Abbreviations: HDS Tukey’s honest significance test, nr no reduction, SEM standard error of the mean
  2. aSignificant reduction compared to infected control group