Table 1 Mean live Amblyomma americanum counts and efficacy relative to placebo at 8 hours after treatment and post-treatment re-infestations for dogs treated with oral sarolaner on Days 0, 30, and 60 or fluralaner once on Day 0

Placebo

Range

17–31

4–18

7–24

9–28

9–30

8–26

7–23

A. mean

23.5

11.6

15.1

15.8

19.9

16.1

17.5

G. mean¹

23.1^a

10.6^a

13.6^a

14.6^a

18.8^a

15.0^a

16.6^a

Sarolaner

Range

6–28

2–15

7–20

9–34

6–18

3–22

10–24

A. mean

16.8

9.3

12.0

17.3

12.8

14.4

16.1

Efficacy (%)

28.7

20.4

20.7

0.0

35.8

10.9

7.9

G. mean¹

15.4^a,b

7.8^a

11.4^a

15.9^a

12.3^a

12.7^a

15.5^a

Efficacy (%)

33.2

26.3

16.1

0.0

34.7

15.3

6.7

P-value vs placebo

0.1338

0.2817

0.5240

0.7543

0.1177

0.5432

0.7973

Fluralaner

Range

2–30

2–17

8–18

5–26

12–27

7–19

11–30

A. mean

16.3

8.1

14.1

19.5

16.6

13.3

17.0

Efficacy (%)

30.9

30.1

6.6

0.0

16.4

17.8

2.9

G. mean¹

12.7^b

7.0^a

13.6^a

17.7^a

16.1^a

12.7^a

16.2^a

Efficacy (%)

45.0

33.8

0.4

0.0

14.0

15.7

2.6

P-value vs placebo

0.0218

0.1317

0.9883

0.4619

0.5580

0.5149

0.9203

P-value vs sarolaner

0.5337

0.7457

0.5867

0.7321

0.3792

0.9889

0.8883