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Table 1 Mean live Amblyomma americanum counts and efficacy relative to placebo at 8 hours after treatment and post-treatment re-infestations for dogs treated with oral sarolaner on Days 0, 30, and 60 or fluralaner once on Day 0

From: Comparative speed of kill of sarolaner (Simparica™ Chewables) and fluralaner (Bravecto®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 14 28 42 58 76 90
Placebo Range 17–31 4–18 7–24 9–28 9–30 8–26 7–23
A. mean 23.5 11.6 15.1 15.8 19.9 16.1 17.5
G. mean1 23.1a 10.6a 13.6a 14.6a 18.8a 15.0a 16.6a
Sarolaner Range 6–28 2–15 7–20 9–34 6–18 3–22 10–24
A. mean 16.8 9.3 12.0 17.3 12.8 14.4 16.1
Efficacy (%) 28.7 20.4 20.7 0.0 35.8 10.9 7.9
G. mean1 15.4a,b 7.8a 11.4a 15.9a 12.3a 12.7a 15.5a
Efficacy (%) 33.2 26.3 16.1 0.0 34.7 15.3 6.7
P-value vs placebo 0.1338 0.2817 0.5240 0.7543 0.1177 0.5432 0.7973
Fluralaner Range 2–30 2–17 8–18 5–26 12–27 7–19 11–30
A. mean 16.3 8.1 14.1 19.5 16.6 13.3 17.0
Efficacy (%) 30.9 30.1 6.6 0.0 16.4 17.8 2.9
G. mean1 12.7b 7.0a 13.6a 17.7a 16.1a 12.7a 16.2a
Efficacy (%) 45.0 33.8 0.4 0.0 14.0 15.7 2.6
P-value vs placebo 0.0218 0.1317 0.9883 0.4619 0.5580 0.5149 0.9203
P-value vs sarolaner 0.5337 0.7457 0.5867 0.7321 0.3792 0.9889 0.8883
  1. 1Geometric means within columns with the same superscript are not significantly different (P > 0.05)