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Table 2 Mean live Amblyomma americanum counts and efficacy relative to placebo at 12 hours after treatment and post-treatment re-infestations for dogs treated with oral sarolaner on Days 0, 30, and 60 or fluralaner once on Day 0

From: Comparative speed of kill of sarolaner (Simparica™ Chewables) and fluralaner (Bravecto®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 14 28 42 58 76 90
Placebo Range 18–32 3–17 7–23 3–27 6–28 7–27 7–25
A. mean 24.1 10.5 15.1 14.3 18.4 14.5 17.3
G. mean1 23.8a 9.3a 13.9a 12.4a 17.2a 13.0a 16.4a
Sarolaner Range 2–15 2–14 8–20 6–24 7–16 3–22 9–23
A. mean 7.3 7.8 11.9 12.6 11.3 11.9 13.9
Efficacy (%) 69.9 26.2 21.5 11.4 38.8 18.1 19.6
G. mean1 5.7c 6.7a,b 11.3a 11.5a 10.9a 9.8a 13.2a
Efficacy (%) 76.0 27.5 18.3 7.5 36.6 24.6 19.0
P-value vs placebo < 0.0001 0.2624 0.4612 0.7786 0.0972 0.3085 0.4375
Fluralaner Range 3–29 0–14 2–19 5–36 15–17 5–19 11–28
A. mean 13.5 5.1 10.5 21.3 15.8 12.0 16.4
Efficacy (%) 44.0 51.2 30.6 0.0 14.3 17.2 5.1
G. mean1 11.1b 3.6b 8.9a 19.1a 15.7a 11.0a 15.6a
Efficacy (%) 53.4 61.4 35.9 0.0 8.7 15.6 4.8
P-value vs placebo 0.0038 0.0012 0.0966 0.1010 0.7241 0.5211 0.8494
P-value vs sarolaner 0.0440 0.0750 0.4523 0.1060 0.2476 0.7240 0.6037
  1. 1Geometric means within columns with the same superscript are not significantly different (P > 0.05)