Comparative speed of kill of sarolaner (Simparica™ Chewables) and fluralaner (Bravecto®) against induced infestations of Amblyomma americanum on dogs

Table 3 Mean live Amblyomma americanum counts and efficacy relative to placebo at 24 hours after treatment and post-treatment re-infestations for dogs with oral sarolaner on Days 0, 30, and 60 or fluralaner once on Day 0

Treatment		Day of treatment or re-infestation
Treatment		0	14	28	42	58	76	90
Placebo	Range	19–31	3–18	8–21	7–37	10–32	6–26	8–21
	A. mean	24.6	10.8	13.1	17.4	19.8	14.9	16.5
	G. mean¹	24.4^a	9.4^a	12.6^a	15.5^a	18.7^a	13.4^a	15.7^a
Sarolaner	Range	0–7	0–2	0–10	0–10	2–14	0–5	0–9
	A. mean	0.9	1.0	3.6	2.8	6.1	1.1	2.6
	Efficacy (%)	96.4	90.7	72.4	84.2	69.0	92.4	84.1
	G. mean¹	0.3^b	0.8^b	2.1^b	1.3^b	5.4^b	0.8^b	1.7^b
	Efficacy (%)	98.8	91.6	83.1	91.6	71.3	94.3	89.4
	P-value vs placebo	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001	< 0.0001
Fluralaner	Range	0–4	0–9	0–11	6–32	13–24	7–18	7–26
	A. mean	0.9	2.6	3.4	19.1	16.9	11.6	15.9
	Efficacy (%)	96.4	75.6	74.3	0.0	14.6	21.8	3.8
	G. mean¹	0.5^b	1.4^b	2.2^b	17.4^a	16.6^a	11.2^a	14.8^a
	Efficacy (%)	97.8	85.2	82.4	0.0	11.5	16.8	5.8
	P-value vs placebo	< 0.0001	< 0.0001	< 0.0001	0.6487	0.6360	0.4870	0.8182
	P-value vs sarolaner	0.5715	0.3246	0.9247	< 0.0001	0.0006	< 0.0001	< 0.0001

¹Geometric means within columns with the same superscript are not significantly different (P > 0.05)

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