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Table 3 Mean live Amblyomma americanum counts and efficacy relative to placebo at 24 hours after treatment and post-treatment re-infestations for dogs with oral sarolaner on Days 0, 30, and 60 or fluralaner once on Day 0

From: Comparative speed of kill of sarolaner (Simparica™ Chewables) and fluralaner (Bravecto®) against induced infestations of Amblyomma americanum on dogs

Treatment   Day of treatment or re-infestation
  0 14 28 42 58 76 90
Placebo Range 19–31 3–18 8–21 7–37 10–32 6–26 8–21
A. mean 24.6 10.8 13.1 17.4 19.8 14.9 16.5
G. mean1 24.4a 9.4a 12.6a 15.5a 18.7a 13.4a 15.7a
Sarolaner Range 0–7 0–2 0–10 0–10 2–14 0–5 0–9
A. mean 0.9 1.0 3.6 2.8 6.1 1.1 2.6
Efficacy (%) 96.4 90.7 72.4 84.2 69.0 92.4 84.1
G. mean1 0.3b 0.8b 2.1b 1.3b 5.4b 0.8b 1.7b
Efficacy (%) 98.8 91.6 83.1 91.6 71.3 94.3 89.4
P-value vs placebo < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001
Fluralaner Range 0–4 0–9 0–11 6–32 13–24 7–18 7–26
A. mean 0.9 2.6 3.4 19.1 16.9 11.6 15.9
Efficacy (%) 96.4 75.6 74.3 0.0 14.6 21.8 3.8
G. mean1 0.5b 1.4b 2.2b 17.4a 16.6a 11.2a 14.8a
Efficacy (%) 97.8 85.2 82.4 0.0 11.5 16.8 5.8
P-value vs placebo < 0.0001 < 0.0001 < 0.0001 0.6487 0.6360 0.4870 0.8182
P-value vs sarolaner 0.5715 0.3246 0.9247 < 0.0001 0.0006 < 0.0001 < 0.0001
  1. 1Geometric means within columns with the same superscript are not significantly different (P > 0.05)