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Table 1 Inhibitory activity of immune sera from the DNA vaccines on the in vitro formation of P. yoelii zygotes and ookinetes

From: Effects of transmission-blocking vaccines simultaneously targeting pre- and post-fertilization antigens in the rodent malaria parasite Plasmodium yoelii

Group Median no. of parasites/well (range) % inhibition of ookinetes
Zygotes Ookinetes
Naïve mice 45.0 (39–51) 13.5 (8–17)  
Vector control 42.0 (37–47) 11.5 (9–14) 14.8
Pys25 2.5 (1–4)a 0.0 (0–1)a 100
Pys48 4.5 (3–6)a 0.5 (0–1)a 96.3
Pys25 + Pys48 6.0 (4–8)a 0.5 (0–1)a 96.3
  1. aSignificant difference compared with the Naïve mice group at P < 0.05 by the Mann-Whitney U-Test