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Table 4 Major clusters of T. brucei specific proteins identified in this study

From: A proteomics approach reveals molecular manipulators of distinct cellular processes in the salivary glands of Glossina m. morsitans in response to Trypanosoma b. brucei infections

Protein family UniProt ID Protein name Functional roles
Variant/invariant surface glycoproteins (VSG/ISG) Q26842 VSG VSGs/ISGs are activated in the SGs; involved in immune evasion/resistance
M4TB38 VSG 1228
M4SU87 VSG 725
Q57VX7 75 kDa ISG
B2ZWC6 ISG
Retrotransposon hot spot protein (RHS) multigene family Q8T9M3 RHS1a RHSs are diverse and potentially rapidly evolving nuclear and perinuclear proteins in T. brucei. RHSs are located in the polymorphic subtelomic regions and may therefore confer selective advantages for the evasion of host immune responses through antigenic variations
Q8T9M7 RHS2a
Q8WPS8 H25N7.12 protein (RHS4)
Q8T9M4 RHS6a
D0A6L8 Putative RHS
D7SGA2 RHS4
Q584N8 Putative RHS
Q585G9 RHS5a
Kinetoplastid calpain/small kinetoplastid calpain-related protein (CALP/SKCRP) protein family Q4GZ11 CALP1.1 CALPs are well-conserved and ubiquitously expressed in tissue-specific isoforms. They are involved in virulence and various physiological (cytoskeleton rearrangement, proliferation, cellular differentiation, interaction with host structures)
C9ZIE8 CALP1.2
Q57WJ7 CALP5.5 V
C9ZT01 CALP7.1
Q387E1 CALP11.6
Q4GZ06 SKCRP1.4
C9ZIF2 SKCRP1.5
C9ZIF6 SKCRP1.7
Paraflagellar/paraxial rod (PRF) protein family C9ZVV0 69 kDa PFR-A 69-kDa and 73-kDa proteins are the major structural components of T. brucei flagellar; Important for parasite motility
C9ZLC1 73 kDa PFR-C
Peroxiredoxin alkyl hydroperoxide reductase C (AhpC)-type family C9ZL57 Tryparedoxin TXN/TXNPx are highly abundant in all life stages of T. brucei; Important in trypanosome metabolism (nucleotide synthesis); and oxidative defence (detoxification of hyperoxides)
C9ZUX7 Tryparedoxin peroxidase
C9ZXT5 Tryparedoxin peroxidase
Bloodstream stage alanine-rich protein (BARP) C9ZZP8 BARP BARPs are GPI-anchored proteins, which are important for cytokinesis; BARPs are proposed to form stage-specific coat for epimastigote forms of T. brucei
O60946 BARP
Q38CW0 BARP
Q38CW1 BARP
C9ZZQ0 BARP
Molecular chaperones; heat shock proteins (Hsp) family C9ZL02 Putative Hsp20 Molecular chaperones are central players in various physiological processes such as protein folding and in maintenance of cellular homeostasis/survival under optimal growth conditions
D0A349 Mitochondrial Hsp60
C9ZR44 Mitochondrial Hsp70
Q383E5 Hsp70
D0A4N5 Hsp83
D0A590 Putative Hsp
Membrane transporters Q388Z2 Plasma membrane ATPase (PMA1) Involved in salvage of nutrients and other metabolites from the host
C9ZK10 ATP synthase subunit beta (ATP5B)
Q581D7 Putative adenosine transporter 1 (ENT1)
Ribosomal proteins (RPs) D0A7E1 RPS5 Involved in the regulation of protein translation
C9ZXI9 RPS7
O76223 RPS12
C9ZRH0 RPS14
D0A2S1 RPS18
C9ZZX2 RPL10a
C9ZYV4 RPL23
  1. Functional roles were inferred from available literature. Only a selection of variant/invariant surface glycoproteins (VSGs/ISGs) is shown in this table (see full list of the isoforms and/or variants in Additional file 1: Table S3)