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Fig. 4 | Parasites & Vectors

Fig. 4

From: The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

Fig. 4

The levels of enzymes involved in the tick hemoglobinolytic pathway vary in a tissue-specific manner in response to A. phagocytophilum infection. Differential expression/representation of tick hemoglobinolytic enzymes in response to A. phagocytophilum infection was obtained from Ayllón et al. [12] and represented by pondering mRNA (transcriptomics RNAseq and real-time RT-PCR) and protein (proteomics) data. In tick midguts, the hemoglobinolytic pathway operating in the endosomal digestive vesicle was revised by Sojka et al. [19]. In tick salivary glands, these enzymes are also produced and may function under different conditions. Abbreviations: AMP, hemoglobin-derived antimicrobial peptides (Hemocidins and other); HRG1, Heme-responsive gene 1; HELP, Heme-binding lipoprotein; VG1, Vitellogenin 1; VG2, Vitellogenin 2

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