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Fig. 5 | Parasites & Vectors

Fig. 5

From: The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

Fig. 5

The digestion of sheep host hemoglobin varies between tick midguts and salivary glands in a tissue-specific manner in response to A. phagocytophilum infection. a Sheep hemoglobin alpha 1/2 (P68240) and beta (P02075) peptides detected by MS analysis with 1 % FDR in midguts and salivary glands from uninfected and A. phagocytophilum-infected ticks. Peptides detected in uninfected and infected (blue), infected (red), or uninfected (green) tick midguts and in uninfected and infected (underlined), infected (bold), or uninfected (italics) tick salivary glands are shown. Hemoglobin protein coverage by detected peptides is highlighted in green. The preferred cleavage sites for Trypsin and hemoglobinolytic enzymes are shown over P1 amino acid for Trypsin (t), Leucine aminopeptidase (l), Legumain (g), Cathepsin B (b), Cathepsin C (c), and Serine carboxypeptidase (s) (see Additional file 3: Dataset S2). b The number of protease genes/proteins different from hemoglobinolytic enzymes and differentially expressed/represented in response to A. phagocytophilum infection in tick midguts and salivary glands were extracted from transcriptomics and proteomics data [12]. c The number of protease inhibitor genes/proteins differentially expressed/represented in response to A. phagocytophilum infection in tick midguts and salivary glands were extracted from transcriptomics and proteomics data [12]

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