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Table 1 Sheep host stress response, transcription/DNA replication, lipid metabolism, and immune response proteins differentially represented in tick midguts and salivary glands in response to A. phagocytophilum infection

From: The intracellular bacterium Anaplasma phagocytophilum selectively manipulates the levels of vertebrate host proteins in the tick vector Ixodes scapularis

ID

Description

Log2 (infected/uninfected) fold change

Function

Midguts

Salivary glands

Stress response proteins

 P31081

HSP60

+2.9

ns

Response to cold

 P0CB32

HSP70

ns

+1.4

Heat shock response

Transcription/DNA replication

 P62803

Histone H4

+3.1

ns

Chromatin structure

 P68432

Histone H3.1

+3.1

ns

Chromatin structure

 F1MN93

TOP1 uncharacterized protein

ns

+2.7

Chromatin binding

Lipid metabolism

 W5QHX9

Phospholipase B

+2.3

-1.3

Lipid absorption

 Q9GL30

Phospholipase B

+1.9

ns

Lipid absorption

 P15497

Apolipoprotein A-I

+1.9

ns

Cholesterol transport

 Q32PF2

ATP-citrate synthase

ns

-1.5

Lipid synthesis

 Q9TTS3

Acetyl-CoA carboxylase 1

ns

-1.6

Lipid synthesis

Immune response

 W5NQK9

S100A8

+3.8

ns

Innate immunity

 W5NQJ0

S100A12

+3.2

ns

Innate immunity

 W5NQH6

S100A9

+3.1

ns

Innate immunity

 P28783

S100A9

+2.6

ns

Innate immunity

 D8X187

Serpin peptidase inhibitor clade B ovalbumin member 1

+2.1

ns

Innate immunity

 P62808

Histone H2B type 1

+3.4

ns

Adaptive immunity

 W5PGJ7

PYD and CARD Domain-Containing uncharacterized protein

+2.9

ns

Adaptive immunity

 P49928

Cathelin-related peptide SC5

+3.1

ns

Anti-bacterial immunity

 P82018

Cathelicidin-2

+2.7

ns

Anti-bacterial immunity

 P50415

Cathelicidin-3

+2.3

ns

Anti-bacterial immunity

 P79360

Myeloid antimicrobial peptide

+2.6

ns

Anti-bacterial immunity

 W5P7S6

Alpha-1-acid glycoprotein

+2.6

nf

Regulation of the immune response

 W5PLV3

RAB5B uncharacterized protein

+2.4

nf

Antigen processing and presentation

 W5PSQ7

Ig-like uncharacterized protein

ns

-1.3

Adaptive immunity

 G5E513

Ig-like uncharacterized protein

ns

-1.8

Adaptive immunity

 G5E5T5

Ig-like uncharacterized protein

ns

-2.7

Adaptive immunity

 F1MQF6

Apoptosis-associated speck-like protein-containing a CARD

nf

-1.5

Innate immunity

 W5PGJ7

LOC101105208 uncharacterized protein

ns

-1.6

Anti-bacterial immunity

  1. Abbreviations: ID protein (Uniprot; http://www.uniprot.org) accession numbers; +, overrepresented proteins in infected vs uninfected ticks; -, underrepresented proteins in infected vs uninfected ticks; nf, not found; ns, not significant