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Fig. 3 | Parasites & Vectors

Fig. 3

From: Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis

Fig. 3

Immunophenotypic features of innate immunity (CD3-CD49b+ NK-cells and CD14+ monocytes) in BALB/c mice immunized with the multicomponent LBSap vaccine, Leish-Tec® or Leishmune®. The x-axis displays the times at which the assays were conducted (before first vaccination [BV], 15 days after third saline [15ASaline] or vaccination [15AVac] and 30 days after experimental L. infantum challenge [30AChal]) in the different analyzed groups (n = 5 mice/group in two independent batches) (Control [□]; Leish-Tec® []; Leishmune® []; and LBSap [killed L. braziliensis vaccine plus saponin; ■]). The y-axis represents the mean values (with standard deviations) of the frequency values in the lymphocytes or monocytes gate. Connecting lines represent significant intra-group differences (P < 0.05) at the different time points. Inter-group differences at the same time point are marked by letters (C: Control group, LT: Leish-Tec® group, LM: Leishmune® group, LB: LBSap group)

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