Fig. 1

Lesion development in WT and TLR^−/− mice upon infection with L. major or L. mexicana. Either 10⁵ L. major promastigotes (a), or L. mexicana promastigotes (b) or amastigotes (c) were used to infect WT, TLR2^−/−, TLR1^−/−, TLR6^−/− and TLR4^−/− mice (n = 4–9) subcutaneously; mice were monitored every week for the appearance and size of lesions. The mean lesion size (mm²) + standard error for each genotype is shown at each weekly time point post-infection, for experiments ending between 12 and 14 weeks. For the L. major infection, the data presented is representative of two experiments. Knockout stains were compared to WT mice using the Mann-Whitney U test, where P < 0.05 was considered to indicate significant (*) differences