Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice

Table 1 Comparison of lesion size to size at peak of infection

	C57Bl/6-UNICAMP^a (Fig. 1a)			C57Bl/6-FIOCRUZ^b (Fig. 1c)			C57Bl/6-UFRJ^c (Fig. 1e)			C57BL6-UFF^d (Fig. 1g)
DPI	t-value (df = 6)	P-value	DPI	t-value (df = 6)	P-value	DPI	t-value (df = 8)	P-value	DPI	t-value (df = 6)	P-value
14	20.77	<0.0001	7	15.46	<0.0001	7	12.08	<0.0001	13	7.371	0.0003
21	12.06	<0.0001	14	14.29	<0.0001	18	11.18	<0.0001	19	6.256	0.0008
28	7.997	0.0002	18	8.697	0.0001	25	10.10	<0.0001	26	4.707	0.0033
35	6.237	0.0008	25	9.102	0.0001	32	6.158	0.0003	33	3.069	0.0220
56	3.381	0.0148	39	9.133	0.0001	39	2.647	0.0294	74	3.706	0.0100
63	4.210	0.0056	46	3.245	0.0176	69	2.395	0.0435	82	3.709	0.0100
70	5.186	0.0020	68	5.106	0.0022	76	3.464	0.0085	89	3.744	0.0096
77	4.490	0.0041	80	5.178	0.0021	87	3.421	0.0091	101	3.948	0.0076
84	5.112	0.0022	89	5.213	0.0020	101	3.151	0.0136	111	3.863	0.0083
91	5.117	0.0022	96	5.404	0.0017	112	3.306	0.0108	117	3.606	0.0113
98	7.532	0.0003	104	5.126	0.0022	126	3.192	0.0128
115	5.733	0.0012

We evaluated mice infection with L. amazonensis (Josefa strain) from different animal facilities: UNICAMP, FIOCRUZ, UFRJ and UFF. The results of the Student’s t-test for lesion size from different times (days post-infection, DPI) with peak of infection are shown; see also Fig. 1
Abbreviations: DPI days post-infection, FIOCRUZ Fundação Oswaldo Cruz, UFF Universidade Federal Fluminense, UFRJ Universidade Federal do Rio de Janeiro, UNICAMP Universidade Estadual de Campinas
^aPeak of infection at day 42 post-infection
^bPeak of infection at day 56 post-infection
^cPeak of infection at day 56 post-infection
^bPeak of infection at day 53 post-infection

ISSN: 1756-3305