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Table 3 Evaluation of LaAg vaccine associated or not with ADDAVACS®

From: Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice

  LaAg vs PBS LaAg vs LaAg + ADDAVACS LaAg + ADDAVACS vs PBS
DPI t-value
(df = 8)
P-value t-value
(df = 8)
P-value t-value
(df = 8)
P-value
21 7.117 0.0001 6.424 0.0002
28 7.363 <0.0001 8.113 <0.0001
35 16.86 <0.0001 5.000 0.0011 20.68 <0.0001
42 16.68 <0.0001 16.71 <0.0001
49 16.58 <0.0001 18.65 <0.0001
56 14.28 <0.0001 12.36 <0.0001
63 13.07 <0.0001 13.46 <0.0001
75 8.180 <0.0001 15.91 <0.0001
  1. . Mice were vaccinated twice with LaAg or LaAg plus ADDAVACS or control (PBS) and then mice were infected. The results of the Student’s t-test for lesion size at different days post-infection between experimental groups (LaAg versus PBS; LaAg versus LaAg plus ADDAVACS; and LaAg plus ADDAVACS versus PBS) are shown; see also Fig. 6a
  2. Abbreviation: DPI days post-infection