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Table 3 Evaluation of LaAg vaccine associated or not with ADDAVACS®

From: Efficacy of intranasal LaAg vaccine against Leishmania amazonensis infection in partially resistant C57Bl/6 mice

 

LaAg vs PBS

LaAg vs LaAg + ADDAVACS

LaAg + ADDAVACS vs PBS

DPI

t-value

(df = 8)

P-value

t-value

(df = 8)

P-value

t-value

(df = 8)

P-value

21

7.117

0.0001

6.424

0.0002

–

–

28

7.363

<0.0001

8.113

<0.0001

–

–

35

16.86

<0.0001

5.000

0.0011

20.68

<0.0001

42

16.68

<0.0001

–

–

16.71

<0.0001

49

16.58

<0.0001

–

–

18.65

<0.0001

56

14.28

<0.0001

12.36

<0.0001

–

–

63

13.07

<0.0001

13.46

<0.0001

–

–

75

8.180

<0.0001

15.91

<0.0001

–

–

  1. . Mice were vaccinated twice with LaAg or LaAg plus ADDAVACS or control (PBS) and then mice were infected. The results of the Student’s t-test for lesion size at different days post-infection between experimental groups (LaAg versus PBS; LaAg versus LaAg plus ADDAVACS; and LaAg plus ADDAVACS versus PBS) are shown; see also Fig. 6a
  2. Abbreviation: DPI days post-infection