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Table 3 Circulating filarial antigen (CFA) and microfilaraemia prevalence rates within 6–7 year-old children and those of 8 years and above from 2009 to 2013

From: Dynamics of antigenemia and transmission intensity of Wuchereria bancrofti following cessation of mass drug administration in a formerly highly endemic region of Mali

 

Survey 1 (2009)

Survey 2 (2011)

Survey 3 (2012)a

Survey 4 (2013)

Sample size and target

Targeted sample size

1,107

1,107

2,530

372

Total population

4,431

4,761

5,044

5,225

Number tested (n)

1,089

1,096

2,097

359

ICT

≥ 8 years % Positive (n/N)

4.9% (39/800)

3.5% (28/795)

2.8% (50/1,812)

 

[95% CI]

[3.53–6.67]

[2.40–5.12]

[2.08–3.65]

–

6–7 years % Positive (n/N)

0% (0/289)

2.7% (8/301)

3.9% (11/285)

4.5% (14/309)

[95% CI]

[0.00–1.64]

[1.24–5.37]

[2.04–7.00]

[2.60–7.66]

Mf

≥ 8 years % Positive (n/N)b

2.6% (1/39)

10.7% (3/28)

0% (0/50)

 

[95% CI]

[0.06–13.48]

[2.81–29.37]

[0.00–8.89]

–

6–7 years % Positive (n/N)b

0

0% (0/8)

0% (0/11)

0% (0/14)

[95% CI]

 

[0.00–40.23]

[0.00–32.15]

[0.00–26.76]

PCR

≥ 8 years % Positive (n/N)

5.13% (2/39)

np

np

np

[95% CI]

[0.89–18.63]

   

6–7 years % Positive (n/N)

0

np

np

np

[95% CI]

    

Wb123

≥ 8 years % Positive (n/N)

np

np

4.7% (2/43)

nd

[95% CI]

  

[0.81–17.06]

 

6–7 years % Positive (n/N)

np

np

1.8% (5/285)

nd

[95% CI]

  

[0.65–4.27]

 

Og4C3

≥ 8 years ICT % Positive (n/N)

np

np

4% (2/50)

np

[95% CI]

  

[0.70–14.86]

 

6–7 years % Positive (n/N)

np

np

1.8% (5/285)

np

[95% CI]

  

[0.65–4.27]

 
  1. Abbreviations: ELISA enzyme-linked immuno-sorbent assay, ICT immunochromatographic card test, ICT+ ICT positive, Mf microfilaraemia, n number positive, N number examined, nd not done, np not planned, PCR polymerase chain reaction, Wb123 filarial antibody test
  2. aIn 2012, the ELISA test was done on all the children and the 50 ICT positive adults
  3. bOnly the ICT positive subjects were tested for Mf