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Fig. 1 | Parasites & Vectors

Fig. 1

From: The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease

Fig. 1

Schematic of the treatment regimen. a Subcutaneous immunization of mice with emulsified PBS, rCsCP or spore coat proteins of B. s-CotC-CsCP administered three times. Serum samples were collected at 2, 4, 6 and 8 weeks. b Oral administration of mice with PBS, spores of B.s-CotC or B.s-CotC-CP, or BL21-CP three times in total, with continuous gavage for three days each time. Serum, intestine and bile samples were collected every 2 weeks. Additionally, serum samples were collected on days 5 and 10 after each administration. Abbreviations: B.s-CotC-CP, WB600 containing pEB03-CotC-CsCP; B.s-CotC, WB600 harbouring pEB03-CotC; BL21-CP, BL21 harbouring pET28a-CsCP

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