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Table 1 Summary of Ixodes scapularis genes selected for RNAi analyses

From: RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

Tick Protein; KEGGa Entry I. scapularis VectorBase accession ID GenBank accession number Predicted function % amino acid identity to H. sapiens ortholog Location of gene on IscaW1 (scaffold: bp range) Number of paralogs identified in IscaW1 assembly Predicted number of protein binding partnersb
Fumarylacetoacetase (FAH) ISCW020196 XP_002407463 Amino acid metabolism 65.9 DS831757: 33,311–44,738 2
Endoplasmic reticulum protein 29 (ERP29) ISCW018425 XP_002435676 Protein folding, sorting, & degradation 17 DS758338: 84,585–88,966 0
Aldehyde dehydrogenase (ALDH) ISCW015982 XP_002399265 Amino acid metabolism 56.7 DS612682: 208,981–240,639 16 6
Carbon-nitrogen hydrolase/pantetheine hydrolase/vanin-like (VNN) ISCW004822 XP_002402506 Metabolism of cofactors & vitamins 33.9 DS712062: 22,027–47,303 0
Malate dehydrogenase (MDH2) ISCW003528 XP_002402153 Carbohydrate metabolism 68.9 DS711115: 47,872–64,175 21
Poly [ADP-ribose] polymerase (PARP) ISCW019519 XP_002409668 DNA replication & repair 48.6 DS807313: 23,492–74,749 2 30
Cytidine/uridine monophosphate kinase (CMPK) ISCW012446 XP_002413690 Nucleotide metabolism 40.2 DS915558: 7422–14,364 3 2
Acetyl-CoA C-acetyltransferase (ACAT1) ISCW016117 XP_002402965 Carbohydrate, lipid, amino acid, terpenoid/polykeytide metabolism 60.2 DS624476: 15,968–41,821 2 24
Hypothetical protein (Hypo195) ISCW011195 XP_002411582 Unknown DS857119: 268,751–271,378
Hypothetical protein (Hypo576) ISCW020576 XP_002408828 Unknown DS835548: 71,893–118,756
  1. aKyoto Encyclopedia of Genes and Genomes;
  2. bNumber of potential protein binding partners as predicted via STRING