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Table 2 Results of RNAi knockdown of I. scapularis transcripts on LGTV infection in ISE6 cells

From: RNAi reveals proteins for metabolism and protein processing associated with Langat virus infection in Ixodes scapularis (black-legged tick) ISE6 cells

Tick Protein VectorBase accession ID Effect of treatment on ISE6 protein expressiona Effect of transcript knockdown on LGTV negative strand replication Effect of transcript knockdown on release of infectious LGTV
   LGTVb UV-LGTVb   
Fumarylacetoacetase (FAH) ISCW020196 Up Up No change Decreased
Endoplasmic reticulum protein 29 (ERP29) ISCW018425 Up Up No change Decreased
Aldehyde dehydrogenase (ALDH) ISCW015982 Up Up No change Decreased
Carbon-nitrogen hydrolase/pantetheine hydrolase/vanin-like (VNN) ISCW004822 Up NC Decreased Decreased
Malate dehydrogenase (MDH2) ISCW003528 Up NC No change Decreased
Poly [ADP-ribose] polymerase (PARP) ISCW019519 Up NC No change No change
Cytidine/uridine monophosphate kinase (CMPK) ISCW012446 Up Up No change Decreased
Acetyl-CoA C-acetyltransferase (ACAT1) ISCW016117 Up Up Decreased Decreased
Hypothetical protein (Hypo195) ISCW011195 Up NC No change Decreased
Hypothetical protein (Hypo576) ISCW020576 Up Up Decreased Decreased
  1. aProtein expression following LGTV and/or UV-LGTV treatment of ISE6 cells compared to mock treatment [4]. Up = increased expression and NC = no statistically-significant change in expression
  2. bLGTV = LGTV infection; UV-LGTV = UV inactivated LGTV treatment