Immune and biochemical responses in skin differ between bovine hosts genetically susceptible and resistant to the cattle tick Rhipicephalus microplus

Table 1 Differentially expressed genes (DEG) found in common across comparisons between stressed reference skins and larvae- or nymph-infested skins from resistant (R) and susceptible (S) tick hosts. Negative and positive values indicate downregulated and upregulated gene expression in skins containing reactions to bites from larvae or nymphs relative to stressed skin (Additional file 7: Table S4)

Gene symbol	Gene title	Log2 FC				% of identity with human ortholog
Gene symbol	Gene title	S-Lar^a	R-Lar^b	S-Nym^c	R-Nym^d	% of identity with human ortholog
Bt.71689 (CLDN11)	Claudin-11	1.11	1.50	1.42	1.73	96
CXCL2 (GRO-2)	Chemokine (C-X-C motif) ligand 2	2.57	2.50	2.47	2.12	74
CCL2	Chemokine (C-C motif) ligand 2	1.20	2.90	3.60	3.61	72
IL8 (CXCL-8)	Interleukin 8	2.82	1.94	2.82	2.34	78
IL6	Interleukin 6 (interferon, beta 2)	2.71	2.99	1.44	2.23	51
CD209	CD209 molecule	1.28	-1.05	1.97	1.42	–

Abbreviations: Lar larvae, Nym nymphs, R resistant tick host, S susceptible tick host, Str stressed skin
^aComparison of stressed skin with Lar skin from susceptible hosts
^bComparison of Str skin with Lar skin from resistant hosts
^cComparison of Str skin with Nym skin from susceptible hosts
^dComparison of Str skin with Nym skin from resistant hosts

ISSN: 1756-3305