Table 2 Differentially expressed genes found in common across comparisons of between skins with tick bites (larvae or nymphs) from resistant and susceptible hosts. Negative and positive values indicate downregulated and upregulated gene expression in skin from tick-resistant hosts as reference groups (Additional file 8: Table S5)
Gene symbol | Gene title | Log2 FC | % of identity with human ortholog | |
|---|---|---|---|---|
R-Lar (ref.) X S-Lara | R-Nym (ref.) X S-Nymb | |||
ALDH1A1 (AL1A1) | Aldehyde dehydrogenase 1 family, member A1 | -1.59 | -1.04 | 91 |
SULT1A1 | Sulfotransferase family, cytosolic, 1A | -1.62 | -1.01 | 84 |
DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | -1.78 | -0.94 | 85 |
SCARA5 | Scavenger receptor class A, member 5 (putative) | -1.45 | -1.11 | 89 |
Bt.23579 LOC785756 | Androgen binding protein beta-like | -8.71 | -6.33 | – |
Bt.19274 (C1QTNF7) | C1q and tumor necrosis factor related protein 7 | -1.79 | -1.00 | 95 |
AKR1C2 | Aldo-keto reductase family 1, member C2 | -2.48 | -1.15 | 72 |
Bt.21056 (DERL1) | Der1-like domain family, member 3 | -0.77 | -1.20 | 83 |
SAA3 | Serum amyloid A 3 | -2.40 | -1.47 | – |
CERS4 | Ceramide synthase 4 | -1.95 | -1.71 | 71 |
AKR1C3 (Bt.63212) | Aldo-keto reductase family 1, member C3 (Prostaglandin F synthase 1-like) | -1.79 | -1.70 | 78 |
SCG2 | Secretogranin II | -2.58 | 1.35 | 87 |
NR4A2 | Nuclear receptor subfamily 4, group A, member 2 | 2.22 | -1.38 | 100 |
TOB1 | Transducer of ERBB2, 1 | 2.67 | 1.17 | 98 |
HMGB1 | High mobility group box 1 | 2.09 | 1.47 | 98 |
IFI6 | Interferon, alpha-inducible protein 6 | 2.39 | 1.14 | 59 |
CSTD | Cathepsin D | 2.64 | 1.29 | 83 |
Pseudogene (HNRNPK) | Heterogeneous nuclear ribonucleoprotein K | 2.71 | 2.09 | 100 |
HNRNPK | Heterogeneous nuclear ribonucleoprotein K | 2.71 | 2.09 | 100 |
IL-3 | Interleukin 3 (colony-stimulating factor, multiple) | 2.32 | 1.80 | 29 |
EIF2AK2 (PKR) | Eukaryotic translation initiation factor 2-alpha kinase 2 | 3.74 | 2.34 | 62 |
SRRM2 | Serine/arginine repetitive matrix 2 | 1.83 | 1.10 | 90 |
NFAT5 | Nuclear factor of activated Tcells 5, tonicity-responsive | 2.15 | 1.35 | 92 |
Bt.25055 (IPMK) | Inositol polyphosphate multikinase | 2.08 | 1.09 | 92 |
CHD4 | Chromodomain helicase DNA binding protein 4 | 2.07 | 1.09 | 99 |
Bt.95322 (MARCKS) | Myristoylated alanine-rich protein kinase C substrate | – | 1.23 | 92 |
AEBP2 | AE binding protein 2 | 2.19 | 1.39 | 97 |
EGFR | Epidermal growth factor receptor | 2.29 | 1.49 | 86 |
MGC155143 | Zinc finger and BTB domain containing 33 | 2.58 | 1.35 | 93 |
JUN | Jun proto-oncogene | 3.16 | 1.11 | 98 |
ISG15 | ISG15 ubiquitin-like modifier | 2.39 | 2.21 | 62 |
PNRC2 | Proline-rich nuclear receptor coactivator 2 | 3.88 | 2.61 | 93 |
FZD10 | Frizzled family receptor 10 | 2.32 | 1.51 | 95 |
PDPK1 | 3-phosphoinositide dependent protein kinase-1 | 2.10 | 1.32 | 94 |
ARPC3 | Actin related protein 2/3 complex, subunit 3 | 2.76 | 1.13 | 100 |
IDH1 | Isocitrate dehydrogenase 1 (NADP+), soluble | 2.53 | 1.26 | 96 |
Pseudogene IDH1 | Isocitrate dehydrogenase 1 (NADP+), soluble | 2.53 | 1.26 | 96 |