Table 3 Differentially expressed genes found in common across comparisons of between skins without tick bites (baseline or stressed) from resistant and susceptible hosts. Negative and positive values indicate downregulated and upregulated gene expression in skin from tick-resistant hosts as reference groups (Additional file 8: Table S5)
Gene symbol | Gene title | Log2FC | % of identity with human ortholog | |
|---|---|---|---|---|
R-Bsl (ref.) X S-Bsla | R-Str (ref.) X S-Strb | |||
ALOX12E | Arachidonate lipoxygenase, epidermal | 3.38 | 2.96 | – |
SYT4 | Synaptotagmin IV | -3.26 | – | 92 |
IGSF5 | Immunoglobulin superfamily, member 5 | -1.20 | -1.83 | 48 |
TDH | L-threonine dehydrogenase | -1.22 | -2.55 | – |
CERS4 | Ceramide synthase 4 | -1.63 | -1.78 | 71 |
FXYD1 | FXYD domain containing ion transport regulator 1 | -1.56 | -1.73 | 90 |
TMC6 | Transmembrane channel-like 6 | -1.28 | -1.12 | 74 |
Bt.70921 KIF3A | Kinesin family member 3A | -1.79 | -2.99 | 99 |
PON3 | Paraoxonase 3 | -4.43 | 2.96 | 81 |
ANKFY1 | Ankyrin repeat and FYVE domain containing 1 | 2.23 | 2.35 | 90 |
TNC | Tenascin C | -2.66 | -1.44 | 86 |
NFU1 | NFU1 iron-sulfur cluster scaffold homolog | -1.08 | -1.22 | 93 |
Bt.28518 | Pancreatic trypsin inhibitor | -1.27 | -1.22 | – |
PECR | Peroxisomal trans-2-enoyl-CoA reductase | -1.50 | -1.94 | 77 |
GNLY | Granulysin | -1.57 | – | 37 |