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Table 1 Participant and methodological characteristics of the studies included in the review

From: Efficacy and safety of praziquantel 40 mg/kg in preschool-aged and school-aged children: a meta-analysis

Species Publication Country End-point (month)a Median age (range, yrs) Attrition Egg count method
Study reference Enrolled (n) Assessed (n) Assessed (%) Risk of bias
S. haematobium
[27] Borrmann et al. (2001) Gabon 2 9 (5–13) 300 296 99 low gm
[28] Davis et al. (1979) Zambia 1 12 (7–17) 151 151 100 low gm
[29] de Clercq et al. (2002) Senegal 2 10.5 (7–14) 288 267 93 low gm
[20] Inyang-Etoh et al. (2009) Nigeria 2 12 (4–20) 312 262 84 high am
[30] Keiser et al. (2010) Ivory coast 1 12 (8–16) 83 83 100 low gm
[31] Keiser et al. (2014) Ivory coast 1 11 (6–16) 78 71 91 low gm + am
[32] Latham et al. (1990) Kenya 2 11 (7–15) 48 48 100 low am
[33] McMahon et al. (1979) Tanzania 1 11 (7–15) 138 125 91 low gm
[34] Midzi et al. (2008) Zimbabwe 2 11 (5–17) 675 624 92 low na
[35] N’goran et al. (2003) Ivory coast 1 10 (5–15) 440 354 80 high gm
[36] Oyideran et al. (1981) Nigeria 1 10 (7–13) 90 82 91 low am
[37] Ojurongbe et al. (2014) Nigeria 1 10 (4–15) 245 245 100 low gm
[38] Ouldabdallahi et al. (2013) Mauritania 1 15 (10–19) 151 151 100 low na
[39] Senghor et al. (2015) Senegal   10 (5–15) 241 237 98 low gm
[40] Sissoko et al. (2009) Mali 1 11 (6–15) 800 781 98 low gm
[41] Stete et al. (2012) Ivory Coast 2 11 (7–15) 98 90 92 low gm + am
[42] Tchuente et al. (2004) Cameroon 1 na, school-aged 674 515 76 high gm
[43] Wilkins et al. (1987) Gambia 1 11 (5–17) 619 619   na gm
S. japonicum
[44] Belizario et al. (2008) Philippines 1 14.5 (10–19) 206 203 99 low gm
[45] Olliaro et al. (2011) Philippines 1 9.5 (7–12) 203 200 99 low gm
S. haematobium, S. japonicum, S. mansoni
[46] Olds et al. (1998) Kenya, Phillipines, China 2 na, school-aged 1,540 1,540 100 low gm
S. mansoni
[47] Barakat et al. (2011) Egypt 2 12 (6–19) 588 588 100 high gm
[48] Barakat et al. (2015) Egypt 2 10 (9–11) 268 194 72 low gm
[49] Berhe et al. (1999) Ethiopia 2 11 (5–17) 611 541 89 high gm
[50] Botros et al. (2005) Egypt 1, 2 14.5 (12–17) 144 103 72 high gm
[51] Degu et al. (2002) Ethiopia 2 12 (10–14) 154 148 96 low am
[52] Erko et al. (2012) Ethiopia 1   224 144 64 low gm
[53] Friis et al. (1988) Botswana 2 na, school-aged 81 81 100 low gm
[54] Gryseels et al. (1987) Burundi 2 12 (5–19) 630 630   na gm
[55] Guisse et al. (1997) Senegal 1 10 (5–15) 130 130 100 low gm
[56] Massoud et al. (1984) Egypt 1 na, school-aged 179 179 100 low gm
[57] Metwally et al. (1995) Egypt 1 12 (8–16) 506 366 72 high gm
[58] Mohamed et al. (2009) Sudan 1 12.5 (8–17) 102 92 90 low gm
[25] Nalugwa et al. (2015) Uganda 1 Pre-school; (1–5) 714 696 97 high gm
[24] Navaratnam et al. (2012) Uganda 1 Pre-school; 3 (1–5) 297 203 68 high am
[59] Obonyo et al. (2010) Kenya 1 9.5 (7–12) 212 204 96 low gm
[38] Ouldabdallahi et al. (2013) Tanzania 1 na, school-aged 271 244 90 low gm
[60] Selim et al. (2014) Egypt 1 11.5 (6–15) 66 66 100   gm
[61] Simonsen et al. (1990) Ethiopia 1 9.5 (5–14) 265 206 78 high gm
[26] Sousa–Figueiredo et al. (2012) Uganda 1 Pre-school; 4 (1–7) 369 305 83 high am
[63] Teesdale et al. (1984) Malawi   12 (9–15) 69 69 100 low am
[62] Thiongo’o et al. (2002) Kenya 2 11 (5–17) 1,018 1,018   na gm
[64] Utzinger et al. (2000 tmih Ivory coast 1 10 (6–14) 253 194 77 high gm
S. mansoni + S. haematobium
[22] Coulibaly et al. (2012) Ivory Coast 1 Pre-school; (0.5–5) 53 53 100 high gm
[65] El Tayeb et al. (1988) Sudan 1 9.5 (7–12) 111 111 100 low na
[23] Garba et al. (2013) Niger 1 Pre-school; (2–5.5) 261 249 95 high gm
[66] Kardaman et al. (1985) Sudan 2 9 (7–11) 220 211 96 low na
[67] Taylor et al. (1988) Zimbabwe 1 12.5 (10–15) 373 283 76 high gm
  1. Abbreviations: am arithmetic mean, gm geometric mean, na not available
  2. a1 month when assessment made at ≤ 1 month; 2 months is > 1 month and ≤ 2 months 5–8 weeks