Table 3 Efficacy, cure rate (CR) and predicted egg reduction rate using geometric mean (pERRgm) by Schistosoma species by age group and PZQ dose
Species | Age category | PZQ dose (mg/kg) | No. of study arms | No. of patients assessed | Reported CR | Reported ERR | Predicted ERR | Ratio ERR reported/predicted | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
% | 95% CI bootstrap | % | % | 95% CI bootstrap | ||||||||
Lower | Upper | Lower | Upper | |||||||||
sh | Pre-school | 40 | 1 | 18 | 88.9 | 74.4 | 99.9 | 98.0 | 97.7 | 94.9 | 99.5 | 1.00 |
syrup 40 | 1 | 161 | 85.7 | 80.3 | 91.1 | 69.4 | 97.1 | 96.1 | 98.1 | 1.40 | ||
Total 40 | 2 | 179 | 87.3 | 85.7 | 88.9 | 83.7 | 97.4 | 97.1 | 97.7 | 1.16 | ||
School-aged | 30 | 2 | 84 | 82.7 | 71.0 | 94.3 | 96.5 | 94.1 | 98.6 | |||
40 | 23 | 3,159 | 72.4 | 63.6 | 81.2 | 90.9 | 94.4 | 92.4 | 96.3 | 1.04 | ||
60 | 2 | 77 | 64.8 | 63.6 | 65.9 | 92.7 | 92.4 | 93.0 | ||||
Total 40 | 25 | 3,338 | 73.6 | 64.8 | 81.7 | 90.9 | 94.7 | 92.7 | 96.4 | 1.04 | ||
sm | Pre-school | 40 | 7 | 806 | 83.1 | 71.1 | 94.3 | 89.7 | 96.6 | 94.2 | 98.6 | 1.08 |
syrup pzq40 | 2 | 182 | 78.0 | 75.0 | 80.9 | 77.9 | 95.6 | 95.0 | 96.2 | 1.23 | ||
2*40 | 4 | 339 | 88.7 | 80.0 | 98.7 | 99.3 | 97.6 | 96.0 | 99.3 | 0.98 | ||
Total 40 | 9 | 988 | 82.0 | 72.6 | 89.9 | 83.1 | 96.4 | 94.5 | 97.9 | 1.16 | ||
School-aged | 10 | 1 | 61 | 26.2 | 15.2 | 37.2 | 78.4 | 69.8 | 84.0 | |||
20 | 4 | 385 | 40.3 | 24.9 | 55.0 | 91.8 | 85.2 | 77.6 | 90.1 | 0.93 | ||
30 | 1 | 197 | 63.0 | 56.3 | 69.7 | 96.1 | 92.3 | 90.5 | 93.9 | 0.96 | ||
40 | 25 | 3,169 | 74.4 | 68.8 | 79.5 | 84.6 | 94.9 | 93.6 | 95.9 | 1.12 | ||
60 | 5 | 667 | 78.6 | 67.8 | 90.0 | 85.1 | 95.7 | 93.4 | 97.9 | 1.13 | ||
Total 40 | 34 | 4,157 | 76.4 | 71.5 | 81.0 | 84.3 | 95.3 | 94.2 | 96.2 | 1.13 | ||
sm + sh | School-aged | 10 | 2 | 73 | 11.2 | 4.2 | 18.1 | 64.9 | 49.5 | 72.6 | ||
20 | 2 | 61 | 38.4 | 36.7 | 40.0 | 84.4 | 83.7 | 85.1 | ||||
30 | 2 | 72 | 51.8 | 31.4 | 72.2 | 89.2 | 81.3 | 94.4 | ||||
40 | 5 | 342 | 67.6 | 54.1 | 80.7 | 98.0 | 93.4 | 89.9 | 96.2 | 0.95 | ||
sj | School-aged | 40 | 3 | 406 | 94.7 | 92.2 | 98.0 | 95.0 | 98.7 | 98.3 | 99.2 | 1.04 |
60 | 2 | 200 | 97.5 | 97.0 | 98.0 | 95.4 | 99.1 | 99.0 | 99.2 | 1.04 | ||