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Table 3 Efficacy, cure rate (CR) and predicted egg reduction rate using geometric mean (pERRgm) by Schistosoma species by age group and PZQ dose

From: Efficacy and safety of praziquantel 40 mg/kg in preschool-aged and school-aged children: a meta-analysis

Species Age category PZQ dose (mg/kg) No. of study arms No. of patients assessed Reported CR Reported ERR Predicted ERR Ratio ERR reported/predicted
% 95% CI bootstrap % % 95% CI bootstrap
Lower Upper Lower Upper
sh Pre-school 40 1 18 88.9 74.4 99.9 98.0 97.7 94.9 99.5 1.00
syrup 40 1 161 85.7 80.3 91.1 69.4 97.1 96.1 98.1 1.40
Total 40 2 179 87.3 85.7 88.9 83.7 97.4 97.1 97.7 1.16
School-aged 30 2 84 82.7 71.0 94.3   96.5 94.1 98.6  
40 23 3,159 72.4 63.6 81.2 90.9 94.4 92.4 96.3 1.04
60 2 77 64.8 63.6 65.9   92.7 92.4 93.0  
Total 40 25 3,338 73.6 64.8 81.7 90.9 94.7 92.7 96.4 1.04
sm Pre-school 40 7 806 83.1 71.1 94.3 89.7 96.6 94.2 98.6 1.08
syrup pzq40 2 182 78.0 75.0 80.9 77.9 95.6 95.0 96.2 1.23
2*40 4 339 88.7 80.0 98.7 99.3 97.6 96.0 99.3 0.98
Total 40 9 988 82.0 72.6 89.9 83.1 96.4 94.5 97.9 1.16
School-aged 10 1 61 26.2 15.2 37.2   78.4 69.8 84.0  
20 4 385 40.3 24.9 55.0 91.8 85.2 77.6 90.1 0.93
30 1 197 63.0 56.3 69.7 96.1 92.3 90.5 93.9 0.96
40 25 3,169 74.4 68.8 79.5 84.6 94.9 93.6 95.9 1.12
60 5 667 78.6 67.8 90.0 85.1 95.7 93.4 97.9 1.13
Total 40 34 4,157 76.4 71.5 81.0 84.3 95.3 94.2 96.2 1.13
sm + sh School-aged 10 2 73 11.2 4.2 18.1   64.9 49.5 72.6  
20 2 61 38.4 36.7 40.0   84.4 83.7 85.1  
30 2 72 51.8 31.4 72.2   89.2 81.3 94.4  
40 5 342 67.6 54.1 80.7 98.0 93.4 89.9 96.2 0.95
sj School-aged 40 3 406 94.7 92.2 98.0 95.0 98.7 98.3 99.2 1.04
60 2 200 97.5 97.0 98.0 95.4 99.1 99.0 99.2 1.04
  1. Abbreviations: ERR egg reduction rate, pERRgm predicted egg reduction rate using geometric mean, CR cure rate, CI confidence interval, sh S. haematobium, sj S. japonicum, sm S. mansoni