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Table 5 Effect of siRNA treatment on microfilaria release by female B. malayi adult parasites

From: RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

Time (h) % inhibition in microfilaria release (mean ± SD)
SCR siRNA1 siRNA2 siRNA1 + 2
24 4.60 ± 0.85 75.4 ± 2.26*** 73.9 ± 5.59*** 79.4 ± 2.20***
48 5.3 ± 1.25 79.7 ± 1.84*** 80.0 ± 2.97*** 81.2 ± 1.96***
72 4.3 ± 0.71 85.3 ± 1.69*** 84.7 ± 2.97*** 86.3 ± 1.20***
96 3.7 ± 1.56 88.3 ± 0.99*** 87.9 ± 2.26*** 88.8 ± 1.69***
120 3.6 ± 1.56 89.5 ± 0.71*** 89.2 ± 2.26*** 90.3 ± 0.99***
  1. Abbreviations: MC medium control; SCR negative control (scrambled siRNA); SD standard deviation
  2. ***P < 0.001