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Table 5 Effect of siRNA treatment on microfilaria release by female B. malayi adult parasites

From: RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

Time (h)

% inhibition in microfilaria release (mean ± SD)

SCR

siRNA1

siRNA2

siRNA1 + 2

24

4.60 ± 0.85

75.4 ± 2.26***

73.9 ± 5.59***

79.4 ± 2.20***

48

5.3 ± 1.25

79.7 ± 1.84***

80.0 ± 2.97***

81.2 ± 1.96***

72

4.3 ± 0.71

85.3 ± 1.69***

84.7 ± 2.97***

86.3 ± 1.20***

96

3.7 ± 1.56

88.3 ± 0.99***

87.9 ± 2.26***

88.8 ± 1.69***

120

3.6 ± 1.56

89.5 ± 0.71***

89.2 ± 2.26***

90.3 ± 0.99***

  1. Abbreviations: MC medium control; SCR negative control (scrambled siRNA); SD standard deviation
  2. ***P < 0.001