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Table 6 Percentage reduction in motility of microfilariae released by B. malayi female adult parasites after in vitro RNA interference was analyzed by scoring their motility

From: RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

Time (h) Reduction in microfilaria motilitya
MC SCR siRNA1 siRNA 2 siRNA1 + 2
24 5+ 5+ 2+ 2+ 1+
48 5+ 5+ 1+ 1+ 1+
72 5+ 5+ 1+/D 1+/D 1+/D
96 5+ 5+ 1+/D 1+/D 1+/D
120 5+ 5+ 1+/D 1+/D 1+/D
  1. Abbreviations: MC medium control; SCR negative control (scrambled siRNA)
  2. a5, 0% motility reduction; 4, 1–25% reduction; 3, 26–49% reduction; 2, 50–74% reduction; 1, 75–99% reduction; D (death), 100% reduction