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Table 7 Effect of siRNA treatment on infective larvae (L3) (mean number ± standard deviation)

From: RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

L3 condition MC SCR siRNA1 + 2
24 h 48 h 24 h 48 h 24 h 48 h
Active (%) 99.0 ± 0.71 96.5 ± 1.41 97.5 ± 0.27 95.7 ± 0.47 14.0 ± 0.71 9.5 ± 0.64
Sluggish (%) 1.0 ± 0.78 3.5 ± 1.42 2.5 ± 0.97 4.2 ± 1.68 76.5 ± 1.97*** 39.2 ± 3.94**
Dead (%) 0 0 0 0 9.50 ± 0.50 51.2 ± 2.83***
  1. Abbreviations: MC medium control; SCR negative control (scrambled siRNA)
  2. **P < 0.01; ***P < 0.001