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Table 7 Effect of siRNA treatment on infective larvae (L3) (mean number ± standard deviation)

From: RNA interference mediated knockdown of Brugia malayi UDP-Galactopyranose mutase severely affects parasite viability, embryogenesis and in vivo development of infective larvae

L3 condition

MC

SCR

siRNA1 + 2

24 h

48 h

24 h

48 h

24 h

48 h

Active (%)

99.0 ± 0.71

96.5 ± 1.41

97.5 ± 0.27

95.7 ± 0.47

14.0 ± 0.71

9.5 ± 0.64

Sluggish (%)

1.0 ± 0.78

3.5 ± 1.42

2.5 ± 0.97

4.2 ± 1.68

76.5 ± 1.97***

39.2 ± 3.94**

Dead (%)

0

0

0

0

9.50 ± 0.50

51.2 ± 2.83***

  1. Abbreviations: MC medium control; SCR negative control (scrambled siRNA)
  2. **P < 0.01; ***P < 0.001