Table 1 Gene mutations identified in miltefosine resistant strain LD843
From: Laboratory confirmed miltefosine resistant cases of visceral leishmaniasis from India
S. No. | Chromosome no. | SNP type | Position in gene | Reference base | Reference cds | Base in LD843 | LD843 cds | Amino acid change |
|---|---|---|---|---|---|---|---|---|
1 | 13 | Non-syn | 1061 | A | TAC | T | TTC | Y354F |
2 | 13 | Syn | 1227 | T | CTA | C | CTC | – |
3 | 13 | Syn | 1267 | T | TTG | C | CTG | – |
4 | 13 | Syn | 2595 | T | GTT | C | GTC | – |
5 | 13 | Non-syn | 3233 | T | TTC | A | TAC | F1078Y |