Visit 1 (enrollment) | Visit 2 (Week 4, Day 28) | Visit 3 (Week 8, Day 56) | Visit 4 (Week 12, Day 84) | |
---|---|---|---|---|
Number of primary dogs | ||||
Fluralaner topical solution | 120 | 110 | 105 | 104 |
Fipronil/(S)-methoprene spot-on solution | 44 | 36 | 36 | 33 |
Arithmetic mean flea count (95% CI) | ||||
Fluralaner topical solution | 149.0 (109.9–188.2) | 0.2 (0.1–0.4) | 0.2 (0.0–0.3) | 0.1 (0.0–0.2) |
Fipronil/(S)-methoprene spot-on solution | 124.7 (78.1–171.3) | 51.4 (16.9–86.0) | 30.8 (10.8–50.9) | 24.0 (3.6–44.4) |
P-value for comparisona | t (161.8) = 0.67, P = 0.5011 | t (152.3) = -4.96, P < 0.0001 | t (150.3) = –5.35, P < 0.0001 | t (106.9) = -4.22, P < 0.0001 |
% efficacy (reduction from baseline) based on arithmetic means | ||||
Fluralaner topical solution | na | 99.8 | 99.9 | 99.9 |
P-value for comparison to baselinea | na | t (162.9) = 8.04, P < 0.0001 | t (162.0) = 8.05, P < 0.0001 | t (161.5) = 7.95, P < 0.0001 |
Fipronil/(S)-methoprene spot-on solution | na | 58.8 | 75.3 | 80.8 |
P-value for comparison to baselinea | na | t (164.4) = 2.51, P = 0.0132 | t (162.4) = 3.10, P = 0.0023 | t (162.6) = 2.93, P = 0.0039 |
Geometric mean flea count (95% CI) | ||||
Fluralaner topical solution | 68.9 (55.2–85.9) | 0.1 (0.1–0.2) | 0.1 (0.0–0.1) | 0.1 (0.0–0.1) |
Fipronil/(S)–methoprene spot-on solution | 66.6 (47.6–93.1) | 12.5 (6.7–22.8) | 6.4 (3.1–12.4) | 4.7 (2.2–9.0) |
P-value for comparisona | t (158.2) = 0.154, P = 0.8782 | t (145.6) = -14.13, P < 0.0001 | t (145.9) = -10.77, P < 0.0001 | t (134.4) = -10.17, P < 0.0001 |
% efficacy (reduction from baseline) based on geometric means | ||||
Fluralaner topical solution | na | 99.8 | 99.9 | 99.9 |
P-value for comparison to baselinea | na | t (158.1) = 34.41, P < 0.0001 | t (156.3) = 32.47, P < 0.0001 | t (155.7) = 31.83, P < 0.0001 |
Fipronil/(S)-methoprene spot-on solution | na | 81.2 | 90.3 | 93.0 |
P-value for comparison to baselinea | na | t (165.5) = 8.32, P < 0.0001 | t (161.1) = 10.40, P < 0.0001 | t (165.5) = 10.95, P < 0.0001 |
% of primary dogs with at least 90% reduction from baseline flea count | ||||
Fluralaner topical solution | na | 100.0 | 100.0 | 98.1 |
Fipronil/(S)-methoprene spot-on solution | na | 38.9 | 55.6 | 54.5 |
P-value for comparisonb | na | Z = -9.11, P < 0.0001 | Z = -7.26, P < 0.0001 | Z = -6.61, P < 0.0001 |
% of flea-free primary dogs | ||||
Fluralaner topical solution | na | 84.5 | 93.3 | 93.3 |
Fipronil/(S)-methoprene spot-on solution | na | 13.9 | 30.6 | 30.3 |
P-value for comparisona | na | Z = -7.83, P < 0.0001 | Z = -7.76, P < 0.0001 | Z = -7.62, P < 0.0001 |