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Table 2 Flea counts for primary dogs enrolled in a field flea-efficacy evaluation of fluralaner topical solution and fipronil/(S)-methoprene. No efficacy comparison was performed at V1 and no primary dogs had 90% reduction or were flea-free at V1

From: A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling canine flea infestations

  Visit 1
(enrollment)
Visit 2
(Week 4, Day 28)
Visit 3
(Week 8, Day 56)
Visit 4
(Week 12, Day 84)
Number of primary dogs
Fluralaner topical solution 120 110 105 104
Fipronil/(S)-methoprene spot-on solution 44 36 36 33
Arithmetic mean flea count (95% CI)
Fluralaner topical solution 149.0 (109.9–188.2) 0.2 (0.1–0.4) 0.2 (0.0–0.3) 0.1 (0.0–0.2)
Fipronil/(S)-methoprene spot-on solution 124.7 (78.1–171.3) 51.4 (16.9–86.0) 30.8 (10.8–50.9) 24.0 (3.6–44.4)
P-value for comparisona t (161.8) = 0.67, P = 0.5011 t (152.3) = -4.96, P < 0.0001 t (150.3) = –5.35, P < 0.0001 t (106.9) = -4.22, P < 0.0001
% efficacy (reduction from baseline) based on arithmetic means
Fluralaner topical solution na 99.8 99.9 99.9
P-value for comparison to baselinea na t (162.9) = 8.04, P < 0.0001 t (162.0) = 8.05, P < 0.0001 t (161.5) = 7.95, P < 0.0001
Fipronil/(S)-methoprene spot-on solution na 58.8 75.3 80.8
P-value for comparison to baselinea na t (164.4) = 2.51, P = 0.0132 t (162.4) = 3.10, P = 0.0023 t (162.6) = 2.93, P = 0.0039
Geometric mean flea count (95% CI)
Fluralaner topical solution 68.9 (55.2–85.9) 0.1 (0.1–0.2) 0.1 (0.0–0.1) 0.1 (0.0–0.1)
Fipronil/(S)–methoprene spot-on solution 66.6 (47.6–93.1) 12.5 (6.7–22.8) 6.4 (3.1–12.4) 4.7 (2.2–9.0)
P-value for comparisona t (158.2) = 0.154, P = 0.8782 t (145.6) = -14.13, P < 0.0001 t (145.9) = -10.77, P < 0.0001 t (134.4) = -10.17, P < 0.0001
% efficacy (reduction from baseline) based on geometric means
Fluralaner topical solution na 99.8 99.9 99.9
P-value for comparison to baselinea na t (158.1) = 34.41, P < 0.0001 t (156.3) = 32.47, P < 0.0001 t (155.7) = 31.83, P < 0.0001
Fipronil/(S)-methoprene spot-on solution na 81.2 90.3 93.0
P-value for comparison to baselinea na t (165.5) = 8.32, P < 0.0001 t (161.1) = 10.40, P < 0.0001 t (165.5) = 10.95, P < 0.0001
% of primary dogs with at least 90% reduction from baseline flea count
Fluralaner topical solution na 100.0 100.0 98.1
Fipronil/(S)-methoprene spot-on solution na 38.9 55.6 54.5
P-value for comparisonb na Z = -9.11, P < 0.0001 Z = -7.26, P < 0.0001 Z = -6.61, P < 0.0001
% of flea-free primary dogs
Fluralaner topical solution na 84.5 93.3 93.3
Fipronil/(S)-methoprene spot-on solution na 13.9 30.6 30.3
P-value for comparisona na Z = -7.83, P < 0.0001 Z = -7.76, P < 0.0001 Z = -7.62, P < 0.0001
  1. a P-value for comparison of model least squares means parameter estimates
  2. b P-value for comparison of percentages using non-parametric asymptotic approach and Standardized Statistic
  3. Abbreviation: na value or calculation is not applicable