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Table 2 Flea counts for primary dogs enrolled in a field flea-efficacy evaluation of fluralaner topical solution and fipronil/(S)-methoprene. No efficacy comparison was performed at V1 and no primary dogs had 90% reduction or were flea-free at V1

From: A randomized, blinded, controlled USA field study to assess the use of fluralaner topical solution in controlling canine flea infestations

 

Visit 1

(enrollment)

Visit 2

(Week 4, Day 28)

Visit 3

(Week 8, Day 56)

Visit 4

(Week 12, Day 84)

Number of primary dogs

Fluralaner topical solution

120

110

105

104

Fipronil/(S)-methoprene spot-on solution

44

36

36

33

Arithmetic mean flea count (95% CI)

Fluralaner topical solution

149.0 (109.9–188.2)

0.2 (0.1–0.4)

0.2 (0.0–0.3)

0.1 (0.0–0.2)

Fipronil/(S)-methoprene spot-on solution

124.7 (78.1–171.3)

51.4 (16.9–86.0)

30.8 (10.8–50.9)

24.0 (3.6–44.4)

P-value for comparisona

t (161.8) = 0.67, P = 0.5011

t (152.3) = -4.96, P < 0.0001

t (150.3) = –5.35, P < 0.0001

t (106.9) = -4.22, P < 0.0001

% efficacy (reduction from baseline) based on arithmetic means

Fluralaner topical solution

na

99.8

99.9

99.9

P-value for comparison to baselinea

na

t (162.9) = 8.04, P < 0.0001

t (162.0) = 8.05, P < 0.0001

t (161.5) = 7.95, P < 0.0001

Fipronil/(S)-methoprene spot-on solution

na

58.8

75.3

80.8

P-value for comparison to baselinea

na

t (164.4) = 2.51, P = 0.0132

t (162.4) = 3.10, P = 0.0023

t (162.6) = 2.93, P = 0.0039

Geometric mean flea count (95% CI)

Fluralaner topical solution

68.9 (55.2–85.9)

0.1 (0.1–0.2)

0.1 (0.0–0.1)

0.1 (0.0–0.1)

Fipronil/(S)–methoprene spot-on solution

66.6 (47.6–93.1)

12.5 (6.7–22.8)

6.4 (3.1–12.4)

4.7 (2.2–9.0)

P-value for comparisona

t (158.2) = 0.154, P = 0.8782

t (145.6) = -14.13, P < 0.0001

t (145.9) = -10.77, P < 0.0001

t (134.4) = -10.17, P < 0.0001

% efficacy (reduction from baseline) based on geometric means

Fluralaner topical solution

na

99.8

99.9

99.9

P-value for comparison to baselinea

na

t (158.1) = 34.41, P < 0.0001

t (156.3) = 32.47, P < 0.0001

t (155.7) = 31.83, P < 0.0001

Fipronil/(S)-methoprene spot-on solution

na

81.2

90.3

93.0

P-value for comparison to baselinea

na

t (165.5) = 8.32, P < 0.0001

t (161.1) = 10.40, P < 0.0001

t (165.5) = 10.95, P < 0.0001

% of primary dogs with at least 90% reduction from baseline flea count

Fluralaner topical solution

na

100.0

100.0

98.1

Fipronil/(S)-methoprene spot-on solution

na

38.9

55.6

54.5

P-value for comparisonb

na

Z = -9.11, P < 0.0001

Z = -7.26, P < 0.0001

Z = -6.61, P < 0.0001

% of flea-free primary dogs

Fluralaner topical solution

na

84.5

93.3

93.3

Fipronil/(S)-methoprene spot-on solution

na

13.9

30.6

30.3

P-value for comparisona

na

Z = -7.83, P < 0.0001

Z = -7.76, P < 0.0001

Z = -7.62, P < 0.0001

  1. a P-value for comparison of model least squares means parameter estimates
  2. b P-value for comparison of percentages using non-parametric asymptotic approach and Standardized Statistic
  3. Abbreviation: na value or calculation is not applicable