Skip to main content

Table 4 Proteases from triatomines

From: Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review

Protease

Species

Synthetic/Natural substrate

Inhibitor

Localization

Role

Reference

Cysteine

Cathepsin L

TBCATL-1; TBCATL-2

Triatoma brasiliensis

Gelatin

E-64; CA-074

Gut

Digestion

[109]

RpCat

Rhodnius prolixus

–

–

Gut

Digestion

[110]

CatL1

Triatoma infestans

–

–

–

Digestion

[111]

Rp-coding sequences

R. prolixus

–

–

Gut

Digestion

[117]

Cathepsin B

CatB1

T. infestans

Z- Phe-Arg-pNA

E-64; CA-074

Gut

Digestion

[111]

Rp-activity

R. prolixus

N-Benzoyl-DL-Arg-β-Napthylamide

–

Gut

Digestion

[113]

Aspartic; Cathepsin D

Rp-activity

R. prolixus

Hb

Pepstatin A

Gut

Immunity

[114]

Ti-coding sequences

T. infestans

–

–

Gut

Immunity

[115]

TiCatD; TiCatD2

T. infestans

MOCAc-GKPILFwFRLK(Dnp)-D-R-NH2

Pepstatin A

Gut

Digestion

[116]

Rp-coding sequences

R. prolixus

–

–

Gut

Digestion

[117]

DmCatD

Dipetalogaster maxima

–

–

Fat body

Yolk formation

[118]

Serine; Trypsin-like

Triapsin

T. infestans

pNA; H-D-Ile-Pro-Arg-pNA

APMSF; SBTI; Antipain

Salivary glands

Haematophagy

[18]

Rn-coding sequences

Rhodnius neglectus

–

–

Salivary glands

Haematophagy

[25]

Metallo

Rp-activity

R. prolixus

Gelatin

1–10 Phenanthroline

Fat body; haemolymph

Immunity

[121, 122]

Astacin

Tm-sequences

Triatoma matogrossensis

–

–

Salivary glands

Haematophagy

[123]

Rp-sequences

R. prolixus

–

–

Oddities

–

 

Rn-coding sequence

R. neglectus

–

–

Salivary glands

Haematophagy

[25]

Reprolysin

Rn-coding sequence

R. neglectus

–

–

Salivary glands

Haematophagy

[25]