Protease | Species | Synthetic/Natural substrate | Inhibitor | Localization | Role | Reference |
---|---|---|---|---|---|---|
Cysteine | ||||||
Cathepsin L | ||||||
TBCATL-1; TBCATL-2 | Triatoma brasiliensis | Gelatin | E-64; CA-074 | Gut | Digestion | [109] |
RpCat | Rhodnius prolixus | – | – | Gut | Digestion | [110] |
CatL1 | Triatoma infestans | – | – | – | Digestion | [111] |
Rp-coding sequences | R. prolixus | – | – | Gut | Digestion | [117] |
Cathepsin B | ||||||
CatB1 | T. infestans | Z- Phe-Arg-pNA | E-64; CA-074 | Gut | Digestion | [111] |
Rp-activity | R. prolixus | N-Benzoyl-DL-Arg-β-Napthylamide | – | Gut | Digestion | [113] |
Aspartic; Cathepsin D | ||||||
Rp-activity | R. prolixus | Hb | Pepstatin A | Gut | Immunity | [114] |
Ti-coding sequences | T. infestans | – | – | Gut | Immunity | [115] |
TiCatD; TiCatD2 | T. infestans | MOCAc-GKPILFwFRLK(Dnp)-D-R-NH2 | Pepstatin A | Gut | Digestion | [116] |
Rp-coding sequences | R. prolixus | – | – | Gut | Digestion | [117] |
DmCatD | Dipetalogaster maxima | – | – | Fat body | Yolk formation | [118] |
Serine; Trypsin-like | ||||||
Triapsin | T. infestans | pNA; H-D-Ile-Pro-Arg-pNA | APMSF; SBTI; Antipain | Salivary glands | Haematophagy | [18] |
Rn-coding sequences | Rhodnius neglectus | – | – | Salivary glands | Haematophagy | [25] |
Metallo | ||||||
Rp-activity | R. prolixus | Gelatin | 1–10 Phenanthroline | Fat body; haemolymph | Immunity | |
Astacin | ||||||
Tm-sequences | Triatoma matogrossensis | – | – | Salivary glands | Haematophagy | [123] |
Rp-sequences | R. prolixus | – | – | Oddities | – |  |
Rn-coding sequence | R. neglectus | – | – | Salivary glands | Haematophagy | [25] |
Reprolysin | ||||||
Rn-coding sequence | R. neglectus | – | – | Salivary glands | Haematophagy | [25] |