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Table 5 Proteases from dipterans

From: Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review

Protease

Species

Synthetic/Natural substrate

Inhibitor

Localization

Role

Reference

Cystein

Cathepsin B

VCB

Aedes aegypti

Z-Arg-Arg-pNA

E-64; Chymostatin

Fat body

Yolk formation

[131]

GmCath B

Glossina morsitans

Hb; Serum albumin

–

Gut

Digestion

[170]

Cathepsin D

mLAP

Ae. aegypti

–

–

Fat body

Yolk formation

[163]

Serine; Trypsin-like

AaET; AaSPVI; AaSPVII

Ae. aegypti

BApNA

–

Gut

Digestion; yolk formation

[137, 138]

AaLT

Ae. aegypti

–

–

Gut

Digestion; yolk formation

[136, 137]

Antryp-7

Anopheles gambiae

–

PMSF

Gut

Digestion

[140–142]

Cq-proteins

Culex quinquefasciatus

–

–

Gut

Digestion

[146]

Aa-proteins

Aedes albopictus

–

–

Gut

Digestion

[149]

ISPL5; ISP13

An. gambiae

–

–

Gut

Immunity

[153, 154]

AgSP14D1

An. gambiae

–

–

Gut

Immunity

[155]

SP14A; SP14D2; SP18D; SP2A

An. gambiae

–

–

Haemolymph

Immunity

[156]

SP22D

An. gambiae

–

–

Haemolymph

Immunity

[157]

ClipSP 1; SerF 2; SerF 3

Anopheles dirus

–

–

Fat body

Immunity

[158]

Pptryp 1-4

Phlebotomus papatasi

BapNa; N-Suc-Ala-Ala-Pro-Phe-pNA

2-nitro-4-carboxyphenyl-N, N-diphenylcarbamate

Gut

Digestion

[164]

Lltryp 1; Lltryp 2

Lutzomyia longipalpis

–

TPCK; PMSF; TLCK

Gut

Digestion

[165, 166]

Chymotrypsin-like

JHA15

Ae. aegypti

N-Suc-Ala-Ala-Pro-Phe-pNA

Chymostatin

Gut

Development

[147]

AaChymo

Ae. aegypti

–

–

Gut

Digestion

[139]

AaSP II-V

Ae. aegypti

–

–

Gut

Digestion

[139]

Aa-protein

Ae. albopictus

–

–

Gut

Digestion

[149]

Anchym 1; Anchym 2

An. gambiae

–

–

Gut

Digestion

[150]

AgChyL

An. gambiae

N-Suc-Ala-Ala-Pro-Phe-pNA

–

Gut

Digestion

[151]

Anachy1; Anachy2

Anopheles aquasalis

Z-Phe-Arg-AMC

PMSF; TLCK

Gut

Digestion

[152]

Andchy1; Andchy2

Anopheles darlingi

–

–

Gut

Digestion

[152]

Ppchym1; Ppchym 2

P. papatasi

BapNa; N-Suc-Ala-Ala-Pro-Phe-pNA

2-nitro-4-carboxyphenyl-N, N-diphenylcarbamate

Gut

Digestion

[164]

Colagenase-like

AaSPI

Ae. aegypti

–

–

Gut

Immunity

[139]

Metallo; Leucine-aminopeptidases

LpNa

Ae. aegypti

Leu-pNa

Leuhistin; Amastatin; Bestatin

Gut

Digestion

[159]

Carboxypeptidase A and B

HPA; HA

Ae. aegypti

Hippuril-Phe; Hippuril-Arg

1–10 Phenanthroline

Gut

Digestion

[159]

MMP

AgMMP 1

An. gambiae

Casein

–

Gut

Digestion; immunity

[160]

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Parasites & Vectors

ISSN: 1756-3305

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