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Table 1 Mean live Ixodes holocyclus counts and efficacy relative to placebo at 8, 12, 24 and 48 h after treatment for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

From: Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ixodes holocyclus on dogs

Treatment   Tick counting time points post-treatment
  8 h 12 h 24 h 48 h
Placebo Range 21–28 20–28 19–28 19–30
Arithmetic mean (AM) 24.13 24.25 23.63 23.75
Geometric mean GM)a 24.00 24.13 23.47 23.53
Sarolaner Range 0–13 0–8 0–0 0–0
Arithmetic mean (AM) 5.13 1.63 0 0
AM Efficacy (%) 78.87 93.30 100 100
Geometric mean (GM)a 3.32 0.76 0 0
GM Efficacy (%) 86.17 96.87 100 100
Test statistic vs placebo t (9) = 5.02 t (8) = 8.65 t (34) = 17.31 t (17) = 58.45
P-value vs placebo 0.0007 < 0.0001 < 0.0001 < 0.0001
Afoxolaner Range 10–28 1–13 0–2 0–0
Arithmetic mean (AM) 20.13 5.00 0.38 0
AM Efficacy (%) 17.01 79.38 98.41 100
Geometric mean (GM)a 18.89 3.63 0.25 0
GM Efficacy (%) 21.28 84.95 98.93 100
Test statistic vs placebo t (9) = 0.65 t (8) = 6.24 t (46) = 11.78 t (17) = 58.45
P-value vs placebo 0.5302 0.0003 < 0.0001 < 0.0001
Test statistic vs sarolaner t (9) = 4.36 t (15) = 2.40 t (70) = 0.74 t (17) = 0.00
P-value vs sarolaner 0.0018 0.0303 0.4622 1.0000
  1. a P-values are based on comparison of geometric means