Treatment
 
Day of study



8

15

22

29

36


Placebo

Range

17–27

20–28

15–26

19–26

19–26

Arithmetic Mean (AM)

21.00

24.13

23.75

22.25

22.88

Geometric Mean (GM)^{a}

20.70

23.95

23.44

22.13

22.78

Sarolaner

Range

0–6

0–1

0–3

0–3

0–3

Arithmetic mean (AM)

1.75

0.25

0.38

1.25

0.75

AM Efficacy (%)

91.67

98.96

98.42

94.38

96.72

Geometric mean (GM)^{a}

1.26

0.19

0.19

0.96

0.49

GM Efficacy (%)

93.93

99.21

99.19

95.67

97.86

Test statistic vs placebo

t
_{(34)} = 12.26

t
_{(34)} = 16.48

t
_{(34)} = 16.37

t
_{(34)} = 13.37

t
_{(34)} = 15.01

Pvalue vs placebo

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Afoxolaner

Range

0–5

0–1

0–6

0–5

0–8

Arithmetic mean (AM)

2.00

0.25

2.75

1.75

2.75

AM Efficacy (%)

90.48

98.96

88.42

92.13

87.98

Geometric mean (GM)^{a}

1.41

0.19

1.78

1.14

1.85

GM Efficacy (%)

93.17

99.21

92.42

94.87

91.89

Test statistic vs placebo

t
_{(46)} = 8.70

t
_{(46)} = 12.06

t
_{(46)} = 8.62

t
_{(46)} = 9.44

t
_{(46)} = 8.41

Pvalue vs placebo

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Test statistic vs sarolaner

t
_{(70)} = 0.22

t
_{(70)} = 0.00

t
_{(70)} = 2.80

t
_{(70)} = 0.29

t
_{(70)} = 2.14

Pvalue vs sarolaner

0.8247

1.0000

0.0066

0.7757

0.0356


^{a}
Pvalues are based on comparison of geometric means