Treatment | Day of study | |||||
---|---|---|---|---|---|---|
8 | 15 | 22 | 29 | 36 | ||
Placebo | Range | 17–27 | 20–28 | 15–26 | 19–26 | 19–26 |
Arithmetic Mean (AM) | 21.00 | 24.13 | 23.75 | 22.25 | 22.88 | |
Geometric Mean (GM)a | 20.70 | 23.95 | 23.44 | 22.13 | 22.78 | |
Sarolaner | Range | 0–6 | 0–1 | 0–3 | 0–3 | 0–3 |
Arithmetic mean (AM) | 1.75 | 0.25 | 0.38 | 1.25 | 0.75 | |
AM Efficacy (%) | 91.67 | 98.96 | 98.42 | 94.38 | 96.72 | |
Geometric mean (GM)a | 1.26 | 0.19 | 0.19 | 0.96 | 0.49 | |
GM Efficacy (%) | 93.93 | 99.21 | 99.19 | 95.67 | 97.86 | |
Test statistic vs placebo | t (34) = 12.26 | t (34) = 16.48 | t (34) = 16.37 | t (34) = 13.37 | t (34) = 15.01 | |
P-value vs placebo | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | |
Afoxolaner | Range | 0–5 | 0–1 | 0–6 | 0–5 | 0–8 |
Arithmetic mean (AM) | 2.00 | 0.25 | 2.75 | 1.75 | 2.75 | |
AM Efficacy (%) | 90.48 | 98.96 | 88.42 | 92.13 | 87.98 | |
Geometric mean (GM)a | 1.41 | 0.19 | 1.78 | 1.14 | 1.85 | |
GM Efficacy (%) | 93.17 | 99.21 | 92.42 | 94.87 | 91.89 | |
Test statistic vs placebo | t (46) = 8.70 | t (46) = 12.06 | t (46) = 8.62 | t (46) = 9.44 | t (46) = 8.41 | |
P-value vs placebo | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | |
Test statistic vs sarolaner | t (70) = 0.22 | t (70) = 0.00 | t (70) = 2.80 | t (70) = 0.29 | t (70) = 2.14 | |
P-value vs sarolaner | 0.8247 | 1.0000 | 0.0066 | 0.7757 | 0.0356 |