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Table 4 Mean live Ixodes holocyclus counts and efficacy relative to placebo at 48 h after weekly re-infestations for dogs treated with a single oral dose of sarolaner or afoxolaner on Day 0

From: Comparative speed of kill of sarolaner (Simparica®) and afoxolaner (NexGard®) against induced infestations of Ixodes holocyclus on dogs

Treatment   Day of study
  9 16 23 30 37
Placebo Range 17–26 20–28 15–26 21–27 19–26
Arithmetic mean (AM) 21.00 24.13 22.00 22.88 22.25
Geometric mean (GM)a 20.79 23.98 21.69 22.80 22.15
Sarolaner Range 0–0 0–2 0–2 0–3 0–1
Arithmetic mean (AM) 0 0.38 0.50 1.25 0.25
AM Efficacy (%) 100 98.45 97.73 94.54 98.88
G. mean (GM)a 0 0.25 0.32 1.03 0.19
GM Efficacy (%) 100 98.95 98.54 95.48 99.15
Test statistic vs placebo t (19) = 54.50 t (25) = 20.30 t (19) = 13.13 t (23) = 12.78 t (26) = 21.67
P-value vs placebo < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001
Afoxolaner Range 0–0 0–1 0–4 0–2 0–1
Arithmetic mean (AM) 0 0.13 1.50 0.38 0.25
AM Efficacy (%) 100 99.48 93.18 98.36 98.88
G. mean (GM)a 0 0.09 1.28 0.25 0.19
GM Efficacy (%) 100 99.62 94.12 98.90 99.15
Test statistic vs placebo t (19) = 54.50 t (25) = 21.23 t (19) = 10.60 t (23) = 15.29 t (26) = 21.67
P-value vs placebo < 0.0001 < 0.0001 < 0.0001 < 0.0001 < 0.0001
Test statistic vs sarolaner t (19) = 0.00 t (25) = 0.93 t (19) = 2.53 t (23) = 2.51 t (26) = 0.00
P-value vs sarolaner 1.0000 0.3606 0.0204 0.0195 1.0000
  1. a P-values are based on comparison of geometric means