Evaluation of protective efficacy induced by different heterologous prime-boost strategies encoding triosephosphate isomerase against Schistosoma japonicum in mice

Table 1 Summary of the protective efficacies of the different immunization groups

Group	No. of mice	Adult worms		Female worms		Eggs in the liver
Group	No. of mice	No. of worms	Reduction (%)	No. of worms	Reduction (%)	No. of eggs	Reduction (%)
Control	11	28 .33 ± 2.55	–	13.67 ± 1.50	–	114,434 ± 17,170	–
DNA vector (i.m.)	12	27.13 ± 6.42	4.26	13.25 ± 3.15	3.05	107,435 ± 25,289	6.12
Ad vector (i.m.)	12	26.50 ± 3.16	6.47	13.00 ± 1.77	4.88	106,826 ± 18,808	6.65
Ad vector (s.c.)	11	26.27 ± 2.72	7.27	12.73 ± 1.35	6.87	109,061 ± 25,571	4.70
DNA (i.m.)	12	19 .22 ± 1.64^a	32.16	9.33 ± 1.00^a	31.71	72,947 ± 26,998^a	36.25
rAdV (i.m.)	12	14.00 ± 4.84^a,b	50.59	6.18 ± 1.94^a,b	54.77	54,883 ± 26,892^a,b	52.04
rAdV (s.c.)	11	18.00 ± 5.24^a	36.47	8.63 ± 2.83^a	36.89	67,077 ± 21,277^a	41.38
rSjTPI (s.c.)	12	20.78 ± 4.52^a	26.67	10.22 ± 2.39^a	25.20	70,993 ± 28,772^a	37.96
DNA (i.m.) + rAdV (i.m.)	11	15.55 ± 4.61^a,c	45.13	6.82 ± 2.71^a,c	50.11	51,991 ± 11,395^a,c	54.57
rAdV (i.m. + s.c.)	12	15.75 ± 6.09^a,d	44.41	7.58 ± 2.81^a,d	44.51	49,095 ± 14,323^a,d	57.10
rAdV (i.m.) + rSjTPI (s.c.)	12	7.91 ± 2.47^a,e	72.09	3.73 ± 1.19^a,e	72.73	31,891 ± 17,776^a,e	72.13

^aStatistically significant differences (P < 0.01), compared to the control or vector control group
^bStatistically significant differences (P < 0.01), compared to the DNA (i.m.), rAdV (s.c.), or rSjTPI (s.c.) group
^cStatistically significant difference (P < 0.01), compared to the DNA (i.m.) group
^dStatistically significant difference (P < 0.05), compared to the rAdV (s.c.) group
^eStatistically significant differences (P < 0.01), compared to each group

ISSN: 1756-3305