Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs

Parasites & Vectors

Table 2 Association between genetic polymorphisms in β-defensin-1 and with Leishmania infantum in dogs from São Raimundo Nonato, Brazil

SNP	Variation ID	Position^a	Alleles	HWE	Possible genotype	Total frequency (n = 95)	Frequency in cases (n = 18)	Frequency in controls (n = 77)	Odds ratio (95% CI)	Logistic regression (P-value)
SNP1	rs852527703	58881447	C/T	0.22	T/T	0.32	0.43	0.26	1.00	0.10
					C/T	0.43	0.43	0.43	0.61 (0.23–1.61)
					C/C	0.25	0.13	0.31	0.26 (0.07–0.95)
SNP2	rs852380685	58881356	C/T	0.22	T/T	0.32	0.43	0.26	1.00	0.10
					C/T	0.43	0.43	0.43	0.61 (0.23–1.61)
					C/C	0.25	0.13	0.31	0.26 (0.07–0.95)
SNP3	rs850814192	58881297	A/G	1	G/G	0.51	0.60	0.46	1.00	0.44
					A/G	0.42	0.33	0.46	0.56 (0.22–1.40)
					A/A	0.07	0.07	0.08	0.67 (0.12–3.80)
SNP4	rs852670798	58881294	A/C	1	C/C	0.48	0.63	0.42	1.00	0.10
					A/C	0.43	0.33	0.48	0.46 (0.18–1.15)
					A/A	0.08	0.03	0.11	0.20 (0.02–1.79)
SNP5	rs852439766	58881277	C/T	0.41	T/T	0.20	0.17	0.22	0.50 (0.14–1.84)	0.47
					C/T	0.55	0.50	0.57	0.57 (0.21–1.56)
					C/C	0.25	0.33	0.22	1.00
SNP6	rs850643698	58881159	A/G	1	G/G	0.08	0.03	0.11	0.20 (0.02–1.79)	0.10
					A/G	0.43	0.33	0.48	0.46 (0.18–1.15)
					A/A	0.48	0.63	0.42	1.00
SNP7	rs853079810	58881122	A/G	0.41	G/G	0.16	0.13	0.17	0.60 (0.15–2.34)	0.67
					A/G	0.54	0.50	0.55	0.68 (0.26–1.78)
					A/A	0.31	0.37	0.28	1.00
SNP8	rs851268228	58881093	C/T	0.82	T/T	0.09	0.07	0.11	0.48 (0.09–2.61)	0.53
					C/T	0.45	0.40	0.48	0.65 (0.26–1.62)
					C/C	0.45	0.53	0.42	1.00
SNP9	rs850702571	58881081	A/G	0.53	G/G	0.64	0.73	0.60	1.00	0.43
					A/G	0.31	0.23	0.34	0.56 (0.21–1.53)
					A/A	0.05	0.03	0.06	0.44 (0.05–4.22)

^aPosition in the reference sequence of canine chromosome 16 (accession number: NC_006598.3)
Abbreviations: SNPs single nucleotide polymorphisms, HWE Hardy-Weinberg equilibrium

ISSN: 1756-3305