Canine β-defensin-1 (CBD1) gene as a possible marker for Leishmania infantum infection in dogs

Parasites & Vectors

Table 3 Association between genetic polymorphisms in β-defensin-1 and with Leishmania infantum in dogs from southern Italy

SNP	Variation ID	Position ^a	Alleles	HWE	Possible genotype	Total frequency (n = 102)	Frequency in cases (n = 33)	Frequency in controls (n = 69)	Odds ratio (95% CI)	Logistic regression (P-value)
SNP1	rs852527703	58881447	C/T	0.16	T/T	0.25	0.30	0.22	0.39 (0.12–1.23)	0.18
					C/T	0.42	0.48	0.39	0.44 (0.16–1.23)
					C/C	0.33	0.21	0.39	1.00
SNP2	rs852380685	58881356	C/T	0.16	T/T	0.25	0.30	0.22	0.39 (0.12–1.23)	0.18
					C/T	0.42	0.48	0.39	0.44 (0.16–1.23)
					C/C	0.33	0.21	0.39	1.00
SNP3	rs850814192	58881297	A/G	0.68	G/G	0.39	0.55	0.32	1.00	0.04
					A/G	0.45	0.39	0.48	2.08 (0.85–5.08)
					A/A	0.16	0.06	0.20	5.73 (1.15–28.57)
SNP4	rs852670798	58881294	A/C	0.24	C/C	0.47	0.30	0.55	1.00	0.05
					A/C	0.47	0.64	0.39	0.34 (0.14–0.83)
					A/A	0.06	0.06	0.06	0.53 (0.08–3.30)
SNP5	rs852439766	58881277	C/T	0.83	T/T	0.14	0.18	0.12	0.30 (0.08–1.15)	0.06
					C/T	0.49	0.61	0.43	0.34 (0.13–0.92)
					C/C	0.37	0.21	0.45	1.00
SNP6	rs850643698	58881159	A/G	0.33	G/G	0.06	0.06	0.06	0.58 (0.09–3.59)	0.11
					A/G	0.46	0.61	0.39	0.39 (0.16–0.95)
					A/A	0.48	0.33	0.55	1.00
SNP7	rs853079810	58881122	A/G	0.67	G/G	0.14	0.18	0.12	0.30 (0.08–1.13)	0.04
					A/G	0.44	0.58	0.38	0.31 (0.12–0.82)
					A/A	0.42	0.24	0.51	1.00
SNP8	rs851268228	58881093	C/T	0.68	T/T	0.18	0.06	0.23	6.80 (1.36–33.88)	0.02
					C/T	0.46	0.42	0.48	2.00 (0.82–4.92)
					C/C	0.36	0.52	0.29	1.00
SNP9	rs850702571	58881081	A/G	1	G/G	0.62	0.45	0.70	1.00	0.07
					A/G	0.34	0.48	0.28	0.37 (0.15–0.90)
					A/A	0.04	0.06	0.03	0.31 (0.04–2.41)

^aPosition in the reference sequence of canine chromosome 16 (accession number: NC_006598.3)
Abbreviations: SNPs single nucleotide polymorphisms, HWE Hardy-Weinberg equilibrium

ISSN: 1756-3305