Meta-analysis of the parasitic phase traits of Haemonchus contortus infection in sheep

Saccareau, Mathilde; Sallé, Guillaume; Robert-Granié, Christèle; Duchemin, Tom; Jacquiet, Philippe; Blanchard, Alexandra; Cabaret, Jacques; Moreno, Carole R.

doi:10.1186/s13071-017-2131-7

Parasites & Vectors

Table 3 The results of the final linear models to estimate each life history trait of the parasitic phase of H. contortus

From: Meta-analysis of the parasitic phase traits of Haemonchus contortus infection in sheep

Life history traits	Explanatory factors	Estimation of means	SE	P
Larval establishment rate (proportion of ingested larvae that develop into immature or adult worms)
Infection duration				0.04
	4–9 dpi	0.09	0.08
	12–16 dpi	0.27	0.05
	21–30 dpi	0.23	0.03
Infection dose				0.004
	4000–5000 L₃	0.25	0.05
	10,000 L₃	0.22	0.03
	16,000–20,000 L₃	0.05	0.07
	30,000 L₃	0.26	0.08
Host age				0.007
	2.5–5 months	0.29	0.06
	5.5–10 months	0.21	0.02
	12–36 months	0.08	0.07
Adult mortality rate (Proportion of adult worms that die per day)
Host GIN resistance status				0.003
	Susceptible	0.039	0.009
	Resistant	0.065	0.011
	Unknwon	0.048	0.009
Isolate status				0.005
	Susceptible to anthelmintics or non-adapted to sheep resistance isolate of H. contortus	0.044	0.009
	Isolate adapted to sheep resistance^a	0.069	0.033
	Isolate resistant to anthelmintics	0.062	0.012
	Unknown	0.026	0.003
Host age				0.005
	1.2–3 months	0.045	0.009
	4.5–8 months	0.059	0.010
	11–12 months	0.047	0.009
Previous host exposure				< 0.001
	Immunologically naive	0.049	0.009
	Suspected natural pre-infection	0.039	0.010
	Experimental abbreviated pre-infection	0.063	0.009
Female fertility (number of eggs/female/day)
Host GIN resistance status				< 0.001
	Susceptible	4545.2	310.0
	Resistant	2740.9	361.5
	Unknown	3465.6	513.1
Infection duration				< 0.001
	27–30 dpi	2136.5	308.9
	41–50 dpi	2270.6	204.3
	70 dpi	6344.7	821.2
Previous exposure of host				< 0.001
	Immunologically naive host	4626.8	372.0
	Experimental pre-infection	2541.0	377.8
Population level fecundity (number of eggs/gram of faeces)^b
Host GIN resistance status				< 0.001
	Susceptible	13536.8	1429.1
	Resistant	4837.4	918.8
	Unknown	9563.8	992.7
Infection duration				0.002
	27–28 dpi	5032.6	1034.9
	30 dpi	18032.4	2575.9
	41–49 dpi	4873.0	415.6

^aBy serial passages in resistant host
^bThe host age was not included in the models for this trait due to a limited dataset
Abbreviation: SE standard error

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ISSN: 1756-3305

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