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Table 1 Functional classification of putative secreted proteins in the RMallHxN dataset comprising eight libraries (UFLRmS, UFLRmR, SGNRmS, SGNRmR, SGMRmS, SGMRmR, SGFRmS and SGFRmR)

From: Mining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations

Functional class Total contigs Total ESTs % of total
Related to host immunitya 12 23 0.29
TIL domain 16 34 0.43
Proteinase inhibitors    
Kunitz domain 30 87 1.10
Serpin 1 2 0.03
Thyropin domains 1 2 0.03
Cystatin 1 1 0.01
Carboxypeptidase inhibitor 2 3 0.04
Lipocalins/histamine binding proteins 35 61 0.77
Immunoglobulin binding proteins 4 57 0.72
Mucins 13 31 0.39
Basic tail family 10 22 0.28
Enzymes    
Metalloproteases 20 48 0.61
Calpain 6 7 0.09
Serine protease 10 42 0.53
Serine carboxypeptidases 2 2 0.03
Antigen 5 family 4 23 0.29
Glycine rich family    
Cement proteins 112 1024 12.92
GYY family 15 70 0.88
GGY family 4 8 0.10
Other secreted proteins 12 13 0.16
R. microplus-specific proteins 107 296 3.74
Unknown secreted 2,082 2,836 35.79
  1. aThese transcripts encoding proteins that may play role in modulation of host immunity. They were classified as “similar to protein associated with interferon”, “microplosin family”, “DAP-36 immunosuppressant family”, “Evasin”, “Defensin” and “Ixoderin” as displayed on Additional file 1