Fig. 3

Temporal haplotype network of P. vivax ama1 _I-II in southern Mexico. a The master network for the entire period (1993–2011). b Haplotype networks in a structure of six layers; the master network was used as a template and each layer represented a three-year period. Each color corresponds to a haplotype (H1-H15) and the size of the ovals is proportional to the number of isolates which share the same haplotype (except for H1 and H8; 0.5 magnification). Solid lines connect the haplotypes; black dots represent the number of mutational steps between haplotypes (including those sampled or extinct). Only the haplotypes detected in each time layer are shown in color