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Table 1 Efficacy of topical imidacloprid + moxidectin combined with oral doxycycline against transplanted adult Dirofilaria immitis. Adult heartworm recovery from necropsy for the control and treated groups. Necropsy was performed on study days 278–282, 10 months post-treatment

From: Assessment of parasitological findings in heartworm-infected beagles treated with Advantage Multi® for dogs (10% imidacloprid + 2.5% moxidectin) and doxycycline

Group Animal ID No. of male worms recovered No. of female worms recovered Totala
Control 43493 3 7 10
43491 4 6 10
43486 5 6 11
43481 5 6 11
43492 3 7 10
43480 5 7 12
43489 4 6 10
43484 4 7 11
Geometric mean 10.6b
Arithmetic mean ± SD 10.625 ± 0.74
Advantage Multi + Doxycycline Treated 43495 0 2 2
43494 0 0 0
43485 0 1 1
43482 0 0 0
43483 1 1 2
43490 0 0 0
43488 0 0 0
43487 0 0 0
Geometric mean 0.44b
Arithmetic mean ± SD 0.625 ± 0.92
Treatment percent efficacy 95.9
  1. aTotal worm counts include intact worms plus non-degenerate fragments. Only 1 was added to the total worm number if non-degenerate fragments could not be identified as distinct worms
  2. bThe average recovery of adult worms for each group was calculated using the geometric mean of each group