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Table 1 In vitro activity of test compounds. Comparison of activity of compounds a-15 and a-17 with tolfenpyrad and tebufenpyrad on the motility of exsheathed third-stage (xL3) and fourth-stage (L4) larvae of Haemonchus contortus (after 24 h, 48 h and 72 h of exposure) and on the development of L4 (after 7 days of exposure)

From: Assessing the anthelmintic activity of pyrazole-5-carboxamide derivatives against Haemonchus contortus

Compound Half maximum inhibitory concentration (IC50 μM)
xL3 motility L4 motility L4 development
24 h 48 h 72 h 24 h 48 h 72 h 7 days
a-15 55.63 ± 0.18 26.31a 3.97 ± 0.35
a-17 51.60 ± 1.41 15.58a 3.42 ± 0.50
Tolfenpyrad 2.98 ± 0.50 3.85 ± 1.33 3.05 ± 0.47 0.12 ± 0.07 0.06 ± 0.02 0.03 ± 0.02 0.08 ± 0.01
Tebufenpyrad na na na > 100 > 100 > 100 6.70a
  1. aHalf maximum inhibitory concentration could not be accurately calculated by the log (agonist) versus response - variable slope (four parameter) equation, a IC50 value was estimated
  2. na no activity; “–” indicates where IC50 values were not determined if the log(agonist) vs response - variable slope (four parameters) model could not be used to fit the curve