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Table 8 Synergists as inhibitors of major metabolic detoxification enzymes

From: Insecticide resistance and resistance mechanisms in bed bugs, Cimex spp. (Hemiptera: Cimicidae)

Insecticide detoxification enzymes

Synergists/inhibitorsa

Cytochrome P450 monooxygenases (P450s)

PBO, sesamex

Esterases

EN16/5–1, DEF, TPP, IBP, K-1, K-2, sesamex, and SV-1

Glutathione S-transferases (GSTs)

DEM, EA and CF

  1. Abbreviations: DEF S.S.S-tributlyphosphorotrithioate, TPP triphenyl phosphate, IBP S-benzyl diisopropyl phosphorothiolate, K-1 (2-phenyl-4H-1,3,2-benzodioxaphosphorothiolate), K-2 2-phenoxy-4H-1,3,2-benzodioxaphosphorin 2-oxide, sesamex 5-[1-[2-(2-ethoxyethoxy) ethoxy]ethoxy]-1,3-benzodioxole, SV-1, O,O-diethyl-O-phenyl phosphorothiolate, DEM diethyl maleate, EA ethacrynic acid, CF chlorfenethol
  2. aData sourced from Brogdon & Chan [286], Heong et al. [147] and Lilly et al. [127]
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Parasites & Vectors

ISSN: 1756-3305

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