Table 1 Half of the maximum inhibition concentration (IC50) values for compounds SNS-032 (MMV690767) and AG-1295 (MMV079840) on the motility of exsheathed third-stage larvae (xL3) and fourth-stage-larvae (L4) of Haemonchus contortus (after 72 h of exposure the compound) and on the development of L4 (7 days of exposure)
Compound | IC50 (μM) | ||
|---|---|---|---|
xL3 motility (72 h) | L4 motility (72 h) | L4 development (7 days) | |
SNS-032 | 12.36a | na | 41.24a |
AG-1295 | 9.92 ± 1.86 | na | 7.75 ± 0.94 |
Monepantel | 0.16 ± 0.08 | 0.37 ± 0.32 | 0.075 ± 0.04 |